Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198857 | 0.77 | CHRNB2 (0.44) | KDM4EMAPTMEN1POLBGAA | |
| SCHEMBL6458723 | 0.73 | CA2 (0.38) | CTSKMAPTCTSSATMCA1 | |
| SCHEMBL10399063 | 0.72 | CHRNB2 (0.60) | RAB9ANPC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL10399064 | 0.72 | CHRNB2 (0.60) | RAB9ANPC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL2837458 | 0.71 | CTSK (0.50) | CTSKCTSSCA1CA2CA7 | |
| SCHEMBL2837459 | 0.71 | CTSK (0.50) | CTSKCTSSCA1CA2CA7 | |
| SCHEMBL5196577 | 0.71 | CTSK (0.67) | CTSKKMT2ACTSSCA1CA2 | |
| SCHEMBL27319770 | 0.69 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL27017370 | 0.69 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL30170161 | 0.69 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556352-A1 | COMPOUNDS CAPABLE OF ACTIVATING CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004031151-A1 | COMPOUNDS CAPABLE OF ACTIVATING CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2004-04-15 | — | — | WO | disclosed |