Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24834707 | 0.86 | MAPT (0.47) | DRD2DRD3CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL24233918 | 0.85 | MBTD1 (0.56) | DRD2DRD3SLC6A2SLC6A4CHRNA7 | |
| SCHEMBL11084741 | 0.84 | DRD2 (0.67) | DRD2DRD3SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL27365078 | 0.84 | ALDH1A1 (0.41) | DRD2DRD3CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL645747 | 0.84 | NPC1 (0.50) | DRD2SIGMAR1KCNH2DRD4HTR1A | |
| SCHEMBL521039 | 0.84 | MAPT (0.62) | CACNA2D1CACNA1BCACNB1CACNA1CKCNH2 | |
| SCHEMBL644789 | 0.83 | BPTF (0.56) | DRD2KCNH2HTR1AHTR7 | |
| SCHEMBL27364621 | 0.83 | MAPT (0.47) | DRD2DRD3CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL22848094 | 0.81 | DRD2 (0.59) | DRD2DRD3SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL13648737 | 0.81 | DRD2 (0.59) | DRD2DRD3SIGMAR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119633-B2 | N-{2-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-ethyl}-N-ethyl-4-methoxy-2,3,6-trimethyl-phenylsulfonamide; condensing the N-carboxyalkyl phenylsulfonamide with the substituted piperidine; bradykinin receptor antagonists; analgesics; antidiabetics; angiogenesis inhibitors; rheumatic diseases | GRUENENTHAL GMBH (DE) | 2012-02-21 | — | — | US | disclosed |