Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.51 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8852559 | 0.92 | DYRK1A (0.53) | DYRK1AALDH1A1KDM4EHPGDGAA | |
| SCHEMBL647613 | 0.87 | DYRK1A (0.55) | DYRK1AALDH1A1KDM4EHPGDGAA | |
| SCHEMBL16123492 | 0.78 | DYRK1A (0.49) | DYRK1AALDH1A1KDM4EHPGDGAA | |
| SCHEMBL30939970 | 0.78 | DYRK1A (0.49) | DYRK1AALDH1A1KDM4EHPGDGAA | |
| SCHEMBL16123486 | 0.75 | KDM4E (0.47) | DYRK1AALDH1A1KDM4EHPGDGAA | |
| SCHEMBL16123491 | 0.73 | DYRK1A (0.55) | DYRK1AALDH1A1KDM4EHPGDGAA | |
| SCHEMBL28503355 | 0.69 | DYRK1A (0.54) | DYRK1AGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30939928 | 0.69 | CCNB2 (0.68) | DYRK1AGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL177685 | 0.69 | CCNB2 (0.68) | DYRK1AGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11350793 | 0.69 | MAPT (0.61) | ALDH1A1KDM4EHPGDGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591738-A | Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof | NDA INTERNATIONAL, INC. (US) | 1997-01-07 | — | — | US | claimed |
| US-20150152187-A1 | Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides | AMBRX, INC. (US) | 2015-06-04 | — | — | US | disclosed |
| EP-2861259-A1 | ANTI-PSMA ANTIBODIES CONJUGATED TO NUCLEAR RECEPTOR LIGAND POLYPEPTIDES | Ambrx, Inc. (US) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013188740-A1 | ANTI-PSMA ANTIBODIES CONJUGATED TO NUCLEAR RECEPTOR LIGAND POLYPEPTIDES | AMBRX, INC. (US) | 2013-12-19 | — | — | WO | disclosed |
| US-8580773-B2 | Small-molecule inhibitors of the androgen receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-11-12 | — | — | US | disclosed |
| US-20130096095-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-04-18 | — | — | US | disclosed |
| US-8354538-B2 | Small-molecule inhibitors of the androgen receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-01-15 | — | — | US | disclosed |
| US-8119660-B2 | Small-molecule inhibitors of the androgen receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-21 | — | — | US | disclosed |
| US-20110224253-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2276345-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | The Regents of the University of California (US) | 2011-01-26 | — | — | EP | disclosed |
| US-20100168128-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-01 | — | — | US | disclosed |
| US-7696227-B2 | Small-molecule inhibitors of the androgen receptor | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-13 | — | — | US | disclosed |
| WO-2009132307-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-29 | — | — | WO | disclosed |
| US-20080293766-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008128100-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096095-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, NR5A1, CYP17A1 | DYRK1A 2516/4885GABRP 215/4885GABRD 223/4885 |
| US-20150152187-A1 | Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides | AR, PSMA1, NR2E3 | DYRK1A 4408/4885GABRP 204/4885GABRD 615/4885 |
| US-20100168128-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, GNRHR, FSHR | DYRK1A 3694/4885GABRP 3400/4885GABRD 2742/4885 |
| US-20080293766-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, GNRHR, FSHR | DYRK1A 3694/4885GABRP 3400/4885GABRD 2742/4885 |
| US-20110224253-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, NR5A1, CYP17A1 | DYRK1A 2516/4885GABRP 215/4885GABRD 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.