Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLI1 | P08151 | 1/20 | 0.38 |
| ▸ | GLI2 | P10070 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 3/20 | 0.38 |
| ▸ | CASP7 | P55210 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8852559 | 0.89 | DYRK1A (0.53) | DYRK1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL646288 | 0.87 | DYRK1A (0.51) | DYRK1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL30939970 | 0.82 | DYRK1A (0.49) | DYRK1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL16123492 | 0.82 | DYRK1A (0.49) | DYRK1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL29817742 | 0.81 | MAPT (0.53) | DYRK1AKDM4EALDH1A1HPGDMAOA | |
| SCHEMBL16123486 | 0.79 | KDM4E (0.47) | DYRK1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL16123491 | 0.77 | DYRK1A (0.55) | DYRK1AKDM4EALDH1A1HPGDGLA | |
| SCHEMBL30939928 | 0.73 | CCNB2 (0.68) | DYRK1AKDM4EALDH1A1HPGDMAOA | |
| SCHEMBL177685 | 0.73 | CCNB2 (0.68) | DYRK1AKDM4EALDH1A1HPGDMAOA | |
| Hydrochloric Acid SCHEMBL647417 | 0.72 | CCNB2 (0.66) | DYRK1AKDM4EALDH1A1HPGDMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591738-A | Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof | NDA INTERNATIONAL, INC. (US) | 1997-01-07 | — | — | US | claimed |
| US-20150152187-A1 | Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides | AMBRX, INC. (US) | 2015-06-04 | — | — | US | disclosed |
| CN-104619350-A | Anti-psma antibodies conjugated to nuclear receptor ligand polypeptides | AMBRX INC | 2015-05-13 | — | — | CN | disclosed |
| EP-2861259-A1 | ANTI-PSMA ANTIBODIES CONJUGATED TO NUCLEAR RECEPTOR LIGAND POLYPEPTIDES | Ambrx, Inc. (US) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013188740-A1 | ANTI-PSMA ANTIBODIES CONJUGATED TO NUCLEAR RECEPTOR LIGAND POLYPEPTIDES | AMBRX, INC. (US) | 2013-12-19 | — | — | WO | disclosed |
| US-8580773-B2 | Small-molecule inhibitors of the androgen receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-11-12 | — | — | US | disclosed |
| US-20130096095-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-04-18 | — | — | US | disclosed |
| US-8354538-B2 | Small-molecule inhibitors of the androgen receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-01-15 | — | — | US | disclosed |
| US-8119660-B2 | Small-molecule inhibitors of the androgen receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-21 | — | — | US | disclosed |
| US-20110224253-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2276345-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | The Regents of the University of California (US) | 2011-01-26 | — | — | EP | disclosed |
| US-20100168128-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-01 | — | — | US | disclosed |
| US-7696227-B2 | Small-molecule inhibitors of the androgen receptor | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-13 | — | — | US | disclosed |
| WO-2009132307-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-29 | — | — | WO | disclosed |
| US-20080293766-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008128100-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-10-23 | — | — | WO | disclosed |
| US-5591738-A | Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof | NDA INTERNATIONAL, INC. (US) | 1997-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096095-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, NR5A1, CYP17A1 | DYRK1A 2516/4885KDM4E 763/4885ALDH1A1 1274/4885 |
| US-20150152187-A1 | Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides | AR, PSMA1, NR2E3 | DYRK1A 4408/4885KDM4E 3840/4885ALDH1A1 2752/4885 |
| US-20100168128-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, GNRHR, FSHR | DYRK1A 3694/4885KDM4E 3293/4885ALDH1A1 987/4885 |
| US-20080293766-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, GNRHR, FSHR | DYRK1A 3694/4885KDM4E 3293/4885ALDH1A1 987/4885 |
| US-20110224253-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, NR5A1, CYP17A1 | DYRK1A 2516/4885KDM4E 763/4885ALDH1A1 1274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.