SCHEMBL6463435

SCHEMBL6463435

CC(C)=CCC/C(C)=C/CC/C(C)=C/CS(=O)(=O)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.49
PGR P06401 1/20 0.49
HTR1A P08908 1/20 0.49
ADORA3 P0DMS8 1/20 0.49
PTGS1 P23219 1/20 0.49
PDE4A P27815 1/20 0.49
MAPK1 P28482 1/20 0.49
DRD3 P35462 1/20 0.49
SNCA P37840 1/20 0.49
PDE3A Q14432 1/20 0.49
CYP3A4 P08684 3/20 0.48
LMNA P02545 2/20 0.48
CYP1A2 P05177 2/20 0.48
CYP2C9 P11712 2/20 0.48
HIF1A Q16665 2/20 0.48
TRPA1 O75762 2/20 0.48
ICMT O60725 1/20 0.48
GMNN O75496 1/20 0.48
POLB P06746 1/20 0.48
TSHR P16473 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2289564 1.00 MAPT (0.49) MAPTPGRHTR1AADORA3PTGS1
SCHEMBL27407686 1.00 MAPT (0.49) MAPTPGRHTR1AADORA3PTGS1
SCHEMBL7930022 1.00 MAPT (0.49) MAPTPGRHTR1AADORA3PTGS1
SCHEMBL28575111 1.00 MAPT (0.49) MAPTPGRHTR1AADORA3PTGS1
SCHEMBL2236562 1.00 MAPT (0.49) MAPTPGRHTR1AADORA3PTGS1
SCHEMBL6028170 1.00 MAPT (0.49) MAPTPGRHTR1AADORA3PTGS1
SCHEMBL14759154 1.00 MAPT (0.49) MAPTPGRHTR1AADORA3PTGS1
SCHEMBL1071266 0.98 MAPT (0.47) MAPTPGRHTR1AADORA3PTGS1
SCHEMBL1071264 0.98 MAPT (0.47) MAPTPGRHTR1AADORA3PTGS1
SCHEMBL16653887 0.98 MAPT (0.47) MAPTPGRHTR1AADORA3PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240400529-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2024-12-05 US disclosed
US-20240368098-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2024-11-07 US disclosed
US-20240293339-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA Stealth Bio Therapeutics Inc. (US) 2024-09-05 US disclosed
US-12049455-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia STEALTH BIOTHERAPEUTICS INC. (US) 2024-07-30 US disclosed
EP-4351547-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA Stealth BioTherapeutics Inc. (US) 2024-04-17 EP disclosed
US-11912654-B2 Process for stereospecific synthesis of vitamin K2 and its novel intermediates SYNERGIA LIFE SCIENCES PVT. LTD. (IN) 2024-02-27 US disclosed
US-11912654-B2 Process for stereospecific synthesis of vitamin K2 and its novel intermediates SYNERGIA LIFE SCIENCES PVT. LTD. (IN) 2024-02-27 US disclosed
US-20230303506-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2023-09-28 US disclosed
US-20230303506-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2023-09-28 US disclosed
US-20230303506-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA STEALTH BIOTHERAPEUTICS INC. (US) 2023-09-28 US disclosed
US-9371301-B2 Prenylarene compound and use thereof OSAKA UNIVERSITY (JP) 2016-06-21 US disclosed
US-20150291498-A1 PROCESS FOR PREPARATION OF MK-7 TYPE OF VITAMIN K2 NATTOPHARMA R&D LTD (CY) 2015-10-15 US disclosed
US-20150210620-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 KAPPA BIOSCIENCE AS (NO) 2015-07-30 US disclosed
US-9012693-B2 Process for the preparation of vitamin K2 KAPPA BIOSCIENCE AS (NO) 2015-04-21 US disclosed
WO-2014058330-A2 PROCESS FOR PREPARATION OF MK-7 TYPE OF VITAMIN K2 INSTYTUT FARMACEUTYCZNY (PL) 2014-04-17 WO disclosed
US-20130065937-A1 NOVEL PRENYLARENE COMPOUND AND USE THEREOF OSAKA UNIVERSITY (JP) 2013-03-14 US disclosed
EP-2567956-A1 NOVEL PRENYLARENE COMPOUND AND USE THEREOF Osaka University (JP) 2013-03-13 EP disclosed
US-20110207967-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 KAPPA BIOSCIENCE AS (NO) 2011-08-25 US disclosed
US-20050124687-A1 Process for synthesizing d-tocotrienols COULADOUROS ELIAS A (GR) 2005-06-09 US disclosed
WO-2005035490-A2 PROCESS FOR SYNTHESIZING d-TOCOTRIENOLS YASOO HEALTH, INC. (US) 2005-04-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240293339-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF VARIOUS MITOCHONDRIAL DISEASES OR DISORDERS, INCLUDING FRIEDREICH'S ATAXIA AIFM2, FH, FECH MAPT 322/4885PGR 3571/4885HTR1A 2964/4885
US-20150291498-A1 PROCESS FOR PREPARATION OF MK-7 TYPE OF VITAMIN K2 SIRT7, PROC, F7 MAPT 4863/4885PGR 462/4885HTR1A 3741/4885
US-20230303506-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA FH, COQ8A, TFAM MAPT 1057/4885PGR 4387/4885HTR1A 3499/4885
US-11912654-B2 Process for stereospecific synthesis of vitamin K2 and its novel intermediates PROC, VKORC1, NADK MAPT 4419/4885PGR 4383/4885HTR1A 4497/4885
US-20130065937-A1 NOVEL PRENYLARENE COMPOUND AND USE THEREOF H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NR1H3, HIF1AN MAPT 4854/4885PGR 737/4885HTR1A 3149/4885
US-20050124687-A1 Process for synthesizing d-tocotrienols UGT8, DDOST, GGPS1 MAPT 4791/4885PGR 3014/4885HTR1A 3367/4885
US-20110207967-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 PROC, VKORC1, VKORC1L1 MAPT 4700/4885PGR 2120/4885HTR1A 4501/4885
US-20150210620-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 PROC, VKORC1, VKORC1L1 MAPT 4724/4885PGR 2164/4885HTR1A 4517/4885
US-20240400529-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA FH, COQ8A, TFAM MAPT 1057/4885PGR 4387/4885HTR1A 3499/4885
US-12049455-B2 Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia FH, COQ8A, TFAM MAPT 1057/4885PGR 4387/4885HTR1A 3499/4885
US-20240368098-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA FH, COQ8A, TFAM MAPT 1057/4885PGR 4387/4885HTR1A 3499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.