Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752087 | 0.81 | P2RX7 (0.53) | HDAC1NPC1RAB9ANTRK1NTRK2 | |
| SCHEMBL32674134 | 0.81 | MAPT (0.59) | HDAC1NPC1RAB9ANTRK1NTRK2 | |
| SCHEMBL21338830 | 0.81 | HDAC1 (0.45) | HDAC1NPC1RAB9ANTRK1NTRK2 | |
| SCHEMBL6311452 | 0.79 | HDAC1 (0.51) | HDAC1NPC1RAB9ANTRK1NTRK2 | |
| SCHEMBL6399279 | 0.78 | KDM4E (0.56) | HDAC1NPC1RAB9ANTRK1NTRK2 | |
| SCHEMBL13543694 | 0.77 | P2RX7 (0.46) | HDAC1NPC1RAB9ANTRK1NTRK2 | |
| SCHEMBL28090836 | 0.77 | HDAC1 (0.51) | HDAC1NPC1RAB9ANTRK1NTRK2 | |
| SCHEMBL23367473 | 0.74 | HDAC1 (0.49) | HDAC1NPC1RAB9ANTRK1NTRK2 | |
| SCHEMBL23354891 | 0.74 | ALDH1A1 (0.52) | NPC1RAB9AP2RX7MEN1KMT2A | |
| SCHEMBL20111441 | 0.74 | NPC1 (0.52) | HDAC1NPC1RAB9ANTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | HDAC1 3559/4885NPC1 778/4885RAB9A 1648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.