Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CETP | P11597 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475534 | 0.89 | SMN1; SMN2 (0.39) | LMNAKMT2AALOX12ALDH1A1SMN1; SMN2 | |
| SCHEMBL7049752 | 0.89 | KMT2A (0.43) | LMNAKMT2ACASP3FFAR2XDH | |
| SCHEMBL7183396 | 0.87 | CTSS (0.44) | LMNAKMT2ACASP3FFAR2ALOX12 | |
| SCHEMBL6467567 | 0.82 | CTSS (0.38) | LMNAKMT2AXDHALOX12ALDH1A1 | |
| SCHEMBL7045311 | 0.78 | KMT2A (0.42) | LMNAKMT2AXDHTP53CASR | |
| SCHEMBL6062139 | 0.77 | CTSS (0.45) | LMNASMN1; SMN2 | |
| SCHEMBL7046968 | 0.77 | ELANE (0.44) | LMNAXDHSMN1; SMN2 | |
| SCHEMBL7048562 | 0.77 | LMNA (0.48) | LMNAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7112203 | 0.76 | CTSS (0.56) | LMNASMN1; SMN2CNR2 | |
| SCHEMBL7045283 | 0.75 | CTSS (0.57) | LMNAKMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |