Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | APAF1 | O14727 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.42 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.42 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.42 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3540123 | 0.98 | MEN1 (0.55) | MEN1KMT2AAPAF1LMNASMN1; SMN2 | |
| SCHEMBL9106300 | 0.80 | MEN1 (0.57) | MEN1KMT2AAPAF1LMNASMN1; SMN2 | |
| SCHEMBL9106305 | 0.80 | MEN1 (0.57) | MEN1KMT2AAPAF1LMNASMN1; SMN2 | |
| SCHEMBL645357 | 0.80 | LTA4H (0.59) | MEN1KMT2AAPAF1LMNASMN1; SMN2 | |
| SCHEMBL646795 | 0.79 | LTA4H (0.50) | ALDH1A1KDM4ENPC1P2RX3TTR | |
| SCHEMBL30657586 | 0.79 | MEN1 (0.49) | MEN1KMT2AAPAF1LMNASMN1; SMN2 | |
| SCHEMBL27094840 | 0.79 | MEN1 (0.49) | MEN1KMT2AAPAF1LMNASMN1; SMN2 | |
| SCHEMBL8551187 | 0.78 | ST14 (0.48) | MEN1KMT2AALDH1A1TSHRTTR | |
| SCHEMBL1338731 | 0.78 | ST14 (0.48) | MEN1KMT2AALDH1A1TSHRTTR | |
| SCHEMBL9109045 | 0.77 | MEN1 (0.53) | MEN1KMT2AAPAF1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119563-B2 | N-substituted azacycles | FMC CORPORATION (US) | 2012-02-21 | — | — | US | disclosed |
| US-8119563-B2 | N-substituted azacycles | FMC CORPORATION (US) | 2012-02-21 | — | — | US | disclosed |
| US-8119563-B2 | N-substituted azacycles | FMC CORPORATION (US) | 2012-02-21 | — | — | US | disclosed |
| US-7683070-B2 | N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines | FMC CORPORATION (US) | 2010-03-23 | — | — | US | disclosed |
| US-20090215821-A1 | N-Substituted Azacycles | FMC CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215821-A1 | N-Substituted Azacycles | FMC CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215821-A1 | N-Substituted Azacycles | FMC CORPORATION | 2009-08-27 | — | — | US | disclosed |
| EP-1673083-A4 | N-SUBSTITUTED AZACYCLES | BAYER CROPSCIENCE AG (DE) | 2008-12-17 | — | — | EP | disclosed |
| US-7365082-B2 | N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines | BAYER CROPSCIENCE AG (DE) | 2008-04-29 | — | — | US | disclosed |
| US-20080090828-A1 | N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines | BAYER CROPSCIENCE AG (DE) | 2008-04-17 | — | — | US | disclosed |
| EP-1572668-A4 | N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL)PIPERIDINES AND PIPERAZINES | FMC CORP (US) | 2006-12-06 | — | — | EP | disclosed |
| EP-1572207-A4 | N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL) PIPERIDINES AND PYRIDINES | FMC CORP (US) | 2006-11-29 | — | — | EP | disclosed |
| US-20060166962-A1 | N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines | FMC CORPORATION | 2006-07-27 | — | — | US | disclosed |
| EP-1673083-A2 | N-SUBSTITUTED AZACYCLES | FMC CORPORATION (US) | 2006-06-28 | — | — | EP | disclosed |
| US-20060135504-A1 | N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines | FMC CORPORATION | 2006-06-22 | — | — | US | disclosed |
| EP-1572207-A1 | N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL) PIPERIDINES AND PYRIDINES | FMC CORPORATION (US) | 2005-09-14 | — | — | EP | disclosed |
| EP-1572668-A2 | N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL)PIPERIDINES AND PIPERAZINES | FMC CORPORATION (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2005036961-A2 | N-SUBSTITUTED AZACYCLES | FMC CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |
| WO-2004060865-A2 | N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL)PIPERIDINES AND PIPERAZINES | FMC CORPORATION (US) | 2004-07-22 | — | — | WO | disclosed |
| WO-2004060371-A1 | N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL) PIPERIDINES AND PYRIDINES | FMC CORPORATION (US) | 2004-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166962-A1 | N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines | DDT, DRD4, DRD1 | MEN1 2452/4885KMT2A 650/4885APAF1 2803/4885 |
| US-20060135504-A1 | N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines | DDT, DRD4, QDPR | MEN1 2174/4885KMT2A 614/4885APAF1 3465/4885 |
| US-20080090828-A1 | N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines | DDT, DRD4, QDPR | MEN1 2020/4885KMT2A 780/4885APAF1 3507/4885 |
| US-20090215821-A1 | N-Substituted Azacycles | DDT, UQCRB, DNMT1 | MEN1 822/4885KMT2A 1219/4885APAF1 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.