Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS8 | Q16651 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 18/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6062946 | 0.92 | PRSS8 (0.40) | PRSS8CTSSCTSLCTSBCTSK | |
| SCHEMBL6062950 | 0.92 | PRSS8 (0.40) | PRSS8CTSSCTSLCTSBCTSK | |
| SCHEMBL7048381 | 0.86 | PRSS8 (0.38) | PRSS8CTSSCTSLCTSBCTSK | |
| SCHEMBL6464676 | 0.81 | CTSS (0.45) | PRSS8CTSSCTSLCTSBCTSK | |
| SCHEMBL6467209 | 0.80 | PRSS8 (0.39) | PRSS8CTSSCTSLCTSBCTSK | |
| SCHEMBL6464410 | 0.78 | FAAH (0.42) | PRSS8CTSSCTSLCTSBCTSK | |
| SCHEMBL7179322 | 0.75 | CTSS (0.52) | PRSS8CTSSCTSLCTSBCTSK | |
| SCHEMBL6061657 | 0.75 | PRSS8 (0.43) | PRSS8CTSSCTSLCTSBCTSK | |
| SCHEMBL6061819 | 0.74 | CTSS (0.61) | PRSS8CTSSCTSLCTSBCTSK | |
| SCHEMBL6466984 | 0.74 | PRSS8 (0.41) | PRSS8CTSSCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |