Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | CTRL | P40313 | 2/20 | 0.42 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 6/20 | 0.41 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | CPA1 | P15085 | 2/20 | 0.41 |
| ▸ | CPA2 | P48052 | 2/20 | 0.41 |
| ▸ | CPA4 | Q9UI42 | 2/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466269 | 1.00 | MMP9 (0.44) | MMP9MMP8MMP14CTSLCTSB | |
| SCHEMBL6466271 | 1.00 | MMP9 (0.44) | MMP9MMP8MMP14CTSLCTSB | |
| SCHEMBL7048648 | 0.90 | CTSL (0.51) | CTSLCTSBCTSSCTSKMMP3 | |
| SCHEMBL6061866 | 0.90 | CTSL (0.51) | CTSLCTSBCTSSCTSKMMP3 | |
| SCHEMBL6061869 | 0.90 | CTSL (0.51) | CTSLCTSBCTSSCTSKMMP3 | |
| SCHEMBL6464784 | 0.89 | ANPEP (0.48) | MMP9MMP8CTSLCTSBCTSS | |
| SCHEMBL6477967 | 0.88 | MMP3 (0.44) | MMP8CTSLCTSBCTSSCTSK | |
| SCHEMBL6467310 | 0.83 | MMP9 (0.44) | MMP9MMP8MMP14CTRLTMPRSS11D | |
| SCHEMBL6464217 | 0.83 | CTSL (0.54) | CTSLCTSBCTSSCTSKMMP3 | |
| SCHEMBL6467305 | 0.83 | MMP9 (0.44) | MMP9MMP8MMP14CTRLTMPRSS11D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |