SCHEMBL6465069

SCHEMBL6465069

COc1ccc(S(=O)(=O)NC(=O)Nc2cccc(NC(=O)NS(=O)(=O)c3ccc(OC)cc3)c2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.64
KCNA1 Q09470 1/20 0.60
KCNAB1 Q14722 1/20 0.60
TSHR P16473 2/20 0.58
TP53 P04637 1/20 0.58
MAPT P10636 3/20 0.58
LMNA P02545 2/20 0.58
ALOX15 P16050 1/20 0.58
MAPK1 P28482 1/20 0.58
TCF4 P15884 1/20 0.56
CTNNB1 P35222 1/20 0.56
KDM4E B2RXH2 1/20 0.56
ALDH1A1 P00352 1/20 0.56
GAA P10253 1/20 0.56
SMN1; SMN2 Q16637 4/20 0.56
HSD17B10 Q99714 2/20 0.56
POLB P06746 2/20 0.53
HTT P42858 1/20 0.53
HRH3 Q9Y5N1 1/20 0.53
KCNK9 Q9NPC2 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6466300 0.92 KCNA1 (0.55) CYP19A1KCNA1KCNAB1TSHRTP53
SCHEMBL7777663 0.90 LMNA (0.71) LMNAALDH1A1GAASMN1; SMN2HSD17B10
SCHEMBL6467685 0.84 HSD17B10 (0.61) KCNA1KCNAB1TP53MAPTLMNA
SCHEMBL8621686 0.84 LMNA (0.62) KCNA1KCNAB1MAPTLMNAALDH1A1
SCHEMBL6241750 0.84 LMNA (0.80) KCNA1KCNAB1TSHRTP53MAPT
SCHEMBL5187356 0.83 CA12 (0.70) TP53MAPTLMNAKDM4EALDH1A1
SCHEMBL9526067 0.82 POLB (0.76) KCNA1KCNAB1TP53SMN1; SMN2HSD17B10
SCHEMBL9526174 0.82 PPIA (0.64) KCNA1KCNAB1SMN1; SMN2HSD17B10POLB
SCHEMBL8662949 0.81 HRH3 (0.72) SMN1; SMN2HSD17B10POLBHRH3CA12
SCHEMBL6467353 0.81 SAE1 (0.71) KCNA1KCNAB1LMNAKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050255998-A1 Mixture of colour developers CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
US-20050106491-A1 Heat sensitive recording material CIBA SPECIALTY CHEMICALS CORP. 2005-05-19 US disclosed
EP-1480836-A1 MIXTURE OF COLOUR DEVELOPERS Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
WO-2003074284-A1 MIXTURE OF COLOUR DEVELOPERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
EP-0792755-B1 Thermosensitive recording material OJI PAPER CO (JP) 1998-11-11 EP disclosed
EP-0792755-A1 Thermosensitive recording material OJI PAPER COMPANY LIMITED (JP) 1997-09-03 EP disclosed
US-5612280-A AROMATIC SULFONYLUREA AND SULFONYLTHIOUREA DERIVATIVES AS COLOR DEVELOPERS; COLORFASTNESS, STORAGE STABILITY, WHITENESS NEW OJI PAPER CO., LTD. (JP) 1997-03-18 US disclosed
EP-0604832-A2 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-07-06 EP disclosed