Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.37 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463980 | 0.82 | PIM1 (0.38) | DAGLARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL6467269 | 0.80 | DAGLA (0.61) | DAGLARAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL8060536 | 0.78 | RAB9A (0.51) | DAGLARAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7042906 | 0.74 | DAGLA (0.46) | DAGLARAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL6466103 | 0.73 | DAGLA (0.56) | DAGLARAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL8060617 | 0.71 | ITGA4 (0.46) | DAGLARAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL2247603 | 0.67 | RAB9A (0.61) | DAGLARAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL7858147 | 0.66 | XDH (0.46) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7736136 | 0.66 | XDH (0.46) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7732480 | 0.66 | HSD17B10 (0.41) | DAGLARAB9ANPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |