Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.57 |
| ▸ | RELA | Q04206 | 2/20 | 0.57 |
| ▸ | PPARD | Q03181 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | TPH1 | P17752 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6328328 | 0.82 | LMNA (0.55) | RAB9ALMNATSHRPPARDPPARA | |
| SCHEMBL28147201 | 0.79 | RAB9A (0.41) | RAB9ALMNATSHRNFKB1NFKB2 | |
| SCHEMBL8892261 | 0.76 | LMNA (0.64) | RAB9ALMNATSHRATMNPC1 | |
| SCHEMBL25002919 | 0.76 | LMNA (0.60) | RAB9ALMNAPPARDPPARAATM | |
| SCHEMBL17513947 | 0.76 | NPC1 (0.57) | RAB9ALMNAPPARDPPARAATM | |
| SCHEMBL1430356 | 0.73 | NR1H4 (0.73) | RAB9ALMNAATMTPH1NPC1 | |
| SCHEMBL12490994 | 0.73 | RAB9A (0.71) | RAB9ALMNATSHRNFKB1NFKB2 | |
| SCHEMBL5661097 | 0.73 | RAB9A (0.68) | RAB9ALMNATSHRNFKB1NFKB2 | |
| SCHEMBL6325229 | 0.72 | LMNA (0.76) | RAB9ALMNATSHRATMNPC1 | |
| SCHEMBL25003157 | 0.72 | GAA (0.69) | RAB9ALMNAPPARDPPARAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423120-A4 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORP (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1423120-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003015785-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2003-02-27 | — | — | WO | disclosed |