Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.48 |
| ▸ | AHR | P35869 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427550 | 0.82 | AHR (0.61) | DYRK1AAHRNPC1RAB9ACYP1B1 | |
| SCHEMBL31243788 | 0.77 | SLC2A1 (0.42) | DYRK1ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL6465009 | 0.77 | ABL1 (0.50) | DYRK1ANPC1RAB9APDGFRBPDGFRA | |
| SCHEMBL6466819 | 0.73 | HRH4 (0.52) | DYRK1ACYP1B1L3MBTL1F2RL3ADORA1 | |
| SCHEMBL27439869 | 0.73 | GABRG2 (0.59) | NPC1RAB9AKDM4EIKBKBALDH1A1 | |
| SCHEMBL17923121 | 0.71 | HSP90AA1 (0.39) | DYRK1ANPC1RAB9AKDM4EADORA2B | |
| SCHEMBL30839853 | 0.71 | HSP90AA1 (0.39) | DYRK1ANPC1RAB9AKDM4EADORA2B | |
| SCHEMBL6461239 | 0.71 | PDGFRB (0.48) | NPC1RAB9APDGFRBPDGFRAALDH1A1 | |
| SCHEMBL11834614 | 0.69 | ALDH1A1 (0.46) | DYRK1ANPC1RAB9AKDM4EADORA2B | |
| SCHEMBL13068145 | 0.68 | ALDH1A1 (0.41) | DYRK1ANPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182105-A1 | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182105-A1 | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function | NR3C2, NR4A3, NR3C1 | DYRK1A 1415/4885AHR 43/4885NPC1 2176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.