Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.50 |
| ▸ | BCR | P11274 | 4/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31243788 | 0.83 | SLC2A1 (0.42) | NPC1RAB9ADYRK1AALDH1A1MEN1 | |
| SCHEMBL6466819 | 0.79 | HRH4 (0.52) | DYRK1A | |
| SCHEMBL29214462 | 0.77 | ALDH1A1 (0.39) | NPC1RAB9ASMN1; SMN2DYRK1AALDH1A1 | |
| SCHEMBL6466797 | 0.77 | DYRK1A (0.48) | PDGFRBPDGFRANPC1RAB9ADYRK1A | |
| SCHEMBL6461239 | 0.76 | PDGFRB (0.48) | PDGFRBPDGFRANPC1RAB9AMAPK1 | |
| SCHEMBL27439869 | 0.72 | GABRG2 (0.59) | NPC1RAB9ATP53CASP3SMN1; SMN2 | |
| SCHEMBL7708814 | 0.72 | DYRK1A (0.65) | ABL1ABCB1BCRESR2NPC1 | |
| SCHEMBL22283952 | 0.71 | HSD17B1 (0.49) | ABL1ABCB1BCRESR2ESR1 | |
| SCHEMBL29870734 | 0.71 | NOS3 (0.47) | NPC1RAB9ASMN1; SMN2DYRK1AALDH1A1 | |
| SCHEMBL2901671 | 0.71 | NOS3 (0.47) | NPC1RAB9ASMN1; SMN2DYRK1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182105-A1 | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY | 2005-08-18 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182105-A1 | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function | NR3C2, NR4A3, NR3C1 | ABL1 3377/4885ABCB1 3399/4885BCR 3626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.