SCHEMBL646703

SCHEMBL646703

O=c1ccc2ccc(F)cc2o1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 4/20 0.59
CA12 O43570 8/20 0.59
CA9 Q16790 8/20 0.59
KDM4E B2RXH2 6/20 0.59
CA1 P00915 6/20 0.59
ALDH1A1 P00352 4/20 0.59
MCL1 Q07820 4/20 0.59
HSD17B10 Q99714 4/20 0.59
GLA P06280 4/20 0.59
AKR1B1 P15121 3/20 0.59
HPGD P15428 3/20 0.59
TDP1 Q9NUW8 3/20 0.59
GAA P10253 3/20 0.59
CASP1 P29466 2/20 0.59
CASP7 P55210 2/20 0.59
ERAP1 Q9NZ08 2/20 0.59
MEN1 O00255 1/20 0.59
KMT2A Q03164 1/20 0.59
CA4 P22748 4/20 0.54
CA5A P35218 4/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30417141 1.00 PGR (0.59) PGRCA12CA9KDM4ECA1
SCHEMBL1094181 0.85 PGR (0.73) PGRCA12CA9KDM4ECA1
SCHEMBL15842518 0.78 CA9 (0.59) PGRCA12CA9KDM4ECA1
SCHEMBL28918550 0.77 PGR (0.63) PGRCA12CA9KDM4ECA1
SCHEMBL5539713 0.76 CA12 (0.61) CA12CA9KDM4ECA1ALDH1A1
SCHEMBL15842877 0.75 POLB (0.49) PGRCA12CA9KDM4ECA1
SCHEMBL5040810 0.74 CA12 (0.59) CA12CA9KDM4ECA1ALDH1A1
SCHEMBL11033273 0.74 CA12 (0.59) CA12CA9KDM4ECA1ALDH1A1
SCHEMBL31331748 0.74 CA12 (0.59) CA12CA9KDM4ECA1ALDH1A1
SCHEMBL7919707 0.74 CA12 (0.59) CA12CA9KDM4ECA1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9127092-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2015-09-08 US claimed
US-20140187725-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2014-07-03 US claimed
US-20250290137-A1 SUBSTITUTED COUMARIN DYES AND USES AS FLUORESCENT LABELS ILLUMINA CAMBRIDGE LIMITED (GB) 2025-09-18 US disclosed
US-12351871-B2 Substituted coumarin dyes and uses as fluorescent labels ILLUMINA CAMBRIDGE LIMITED (GB) 2025-07-08 US disclosed
US-20240271209-A1 SUBSTITUTED COUMARIN DYES AND USES AS FLUORESCENT LABELS ILLUMINA CAMBRIDGE LIMITED (GB) 2024-08-15 US disclosed
US-20240213536-A1 Lithium Secondary Battery LG ENERGY SOLUTION, LTD. (KR) 2024-06-27 US disclosed
US-20240213536-A1 Lithium Secondary Battery LG ENERGY SOLUTION, LTD. (KR) 2024-06-27 US disclosed
US-11981964-B2 Substituted coumarin dyes and uses as fluorescent labels ILLUMINA CAMBRIDGE LIMITED (GB) 2024-05-14 US disclosed
WO-2023219474-A1 NON-AQUEOUS ELECTROLYTE AND LITHIUM SECONDARY BATTERY COMPRISING SAME 주식회사 엘지에너지솔루션 2023-11-16 WO disclosed
EP-4188921-A1 SUBSTITUTED COUMARIN DYES AND USES AS FLUORESCENT LABELS Illumina Cambridge Limited (GB) 2023-06-07 EP disclosed
CN-115867544-A Substituted coumarin dyes and their use as fluorescent labels 伊鲁米纳剑桥有限公司 2023-03-28 CN disclosed
US-20090005580-A1 Compounds, compositions and methods CYTOKINETICS, INC. 2009-01-01 US disclosed
EP-1511734-A4 COMPOUNDS, COMPOSITIONS, AND METHODS CYTOKINETICS INC (US) 2006-05-10 EP disclosed
US-20060020008-A1 Treating cell proliferation disorder, anticancer agents CYTOKINETICS, INC. 2006-01-26 US disclosed
US-6924376-B2 Compounds, compositions and methods CYTOKINETICS, INC. (US) 2005-08-02 US disclosed
EP-1511734-A2 COMPOUNDS, COMPOSITIONS, AND METHODS Cytokinetics, Inc. (US) 2005-03-09 EP disclosed
WO-2003088903-A2 COMPOUNDS, COMPOSITIONS, AND METHODS CYTOKINETICS, INC. (US) 2003-10-30 WO disclosed
EP-0185319-B1 FLUORO COUMARINS AS ANTILYMPHOEDEMA AGENTS BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1989-09-06 EP disclosed
US-4749798-A ANTIINFLAMMATORY, ANTISWELLING BOEHRINGER BIOCHEMIA ROBIN SPA (IT) 1988-06-07 US disclosed
EP-0185319-A2 Fluoro coumarins as antilymphoedema agents BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1986-06-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11981964-B2 Substituted coumarin dyes and uses as fluorescent labels FBL, DUT, PHAX PGR 1849/4885CA12 4179/4885CA9 3934/4885
US-20060020008-A1 Treating cell proliferation disorder, anticancer agents MKI67, PCNA, TK1 PGR 1555/4885CA12 3242/4885CA9 4129/4885
US-20090005580-A1 Compounds, compositions and methods ALPP, PCNA, MKI67 PGR 714/4885CA12 1601/4885CA9 2719/4885
US-20250290137-A1 SUBSTITUTED COUMARIN DYES AND USES AS FLUORESCENT LABELS FBL, DUT, PHAX PGR 1849/4885CA12 4179/4885CA9 3934/4885
US-20240271209-A1 SUBSTITUTED COUMARIN DYES AND USES AS FLUORESCENT LABELS FBL, DUT, PHAX PGR 1849/4885CA12 4179/4885CA9 3934/4885
US-12351871-B2 Substituted coumarin dyes and uses as fluorescent labels FBL, DUT, PHAX PGR 1849/4885CA12 4179/4885CA9 3934/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.