Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 4/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931338 | 0.85 | GAA (0.44) | GAALMNAPKMKMT2ANAMPT | |
| SCHEMBL4190316 | 0.85 | NAMPT (0.44) | GAALMNAPKMKMT2ANAMPT | |
| SCHEMBL4202489 | 0.77 | GAA (0.49) | GAAPKMKMT2ANAMPTPTGS2 | |
| SCHEMBL6469174 | 0.77 | PTGS2 (0.52) | LMNAKMT2ANAMPTPTGS2SMN1; SMN2 | |
| SCHEMBL6532215 | 0.77 | PDE4D (0.43) | PTGS2 | |
| SCHEMBL6527184 | 0.76 | PTGS2 (0.42) | GAALMNAPTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4202149 | 0.74 | NAMPT (0.46) | GAALMNAKMT2ANAMPTALDH1A1 | |
| SCHEMBL6532108 | 0.73 | PDE4D (0.42) | LMNA | |
| SCHEMBL4200530 | 0.72 | BRD4 (0.43) | GAANAMPTALDH1A1SMPD1KDM4E | |
| SCHEMBL6528413 | 0.72 | PIK3CA (0.42) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569908-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004046113-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |