Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532215 | 0.81 | PDE4D (0.43) | PTGS2PTGS1EGFRPDE4APDE4B | |
| SCHEMBL6527184 | 0.81 | PTGS2 (0.42) | PTGS2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6468561 | 0.77 | GAA (0.40) | PTGS2MEN1KMT2ANAMPTSMN1; SMN2 | |
| SCHEMBL4194215 | 0.76 | PDE4A (0.51) | PTGS2PTGS1MEN1KMT2APDE4A | |
| SCHEMBL6071519 | 0.75 | PTGS2 (0.55) | PTGS2PTGS1EGFRBCL2L1MCL1 | |
| SCHEMBL4188752 | 0.74 | PTGS2 (0.41) | PTGS2PTGS1MEN1KMT2APDE4A | |
| SCHEMBL6470005 | 0.72 | MAPT (0.40) | L3MBTL1MEN1KMT2APDE4APDE4B | |
| SCHEMBL6528413 | 0.72 | PIK3CA (0.42) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL2926474 | 0.72 | POLB (0.55) | PTGS2MEN1KMT2APDE4APDE4B | |
| SCHEMBL6532108 | 0.70 | PDE4D (0.42) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569908-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004046113-A2 | PYRIDINE N-OXIDE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |