Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31412830 | 0.84 | LOXL2 (0.50) | LMNAHTTSMN1; SMN2MAPTADRA2C | |
| SCHEMBL3741348 | 0.81 | ALDH1A1 (0.50) | LMNAHTTSMN1; SMN2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL5395461 | 0.79 | ALDH1A1 (0.49) | LMNAHTTSMN1; SMN2NAMPTALDH1A1 | |
| SCHEMBL14548719 | 0.78 | LMNA (0.47) | LMNASMN1; SMN2MAPTMAPK1HDAC3 | |
| SCHEMBL2893366 | 0.78 | MEN1 (0.50) | MAPTHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL318675 | 0.77 | CYP1A2 (0.58) | HTTSMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL11560498 | 0.77 | MAPT (0.52) | MAPTHDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL22186340 | 0.76 | ADRA2C (0.46) | LMNAHTTSMN1; SMN2ADRA2CALDH1A1 | |
| SCHEMBL3266830 | 0.73 | HRH4 (0.58) | LMNAHTTSMN1; SMN2MAPTNAMPT | |
| SCHEMBL2188159 | 0.72 | HRH4 (0.67) | LMNAHTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049593-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-06-02 | — | — | WO | disclosed |