Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.41 |
| ▸ | IL6 | P05231 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468944 | 0.81 | SIRT6 (0.44) | SIRT6TSHRKMT2AOPRM1OPRD1 | |
| SCHEMBL5132527 | 0.81 | SIRT6 (0.41) | SIRT6TSHRMEN1KMT2AL3MBTL1 | |
| SCHEMBL6470753 | 0.79 | SIRT6 (0.40) | SIRT6TSHRALDH1A1OPRM1OPRD1 | |
| SCHEMBL6468988 | 0.78 | TLR7 (0.44) | TLR7IL6TSHRMEN1CYP1A2 | |
| SCHEMBL30874231 | 0.77 | SIRT6 (0.49) | SIRT6TLR7IL6TSHRKMT2A | |
| SCHEMBL6468945 | 0.77 | SIRT6 (0.42) | SIRT6HCAR3LMNATSHRMEN1 | |
| SCHEMBL29684052 | 0.75 | SIRT6 (0.50) | SIRT6HCAR3LMNAKDM4ETSHR | |
| SCHEMBL5134062 | 0.73 | OPRM1 (0.52) | SIRT6KDM4EOPRM1OPRD1OPRK1 | |
| SCHEMBL5042470 | 0.70 | HCAR3 (0.46) | SIRT6HCAR3LMNAKDM4ETSHR | |
| SCHEMBL2635320 | 0.70 | SIRT6 (0.73) | SIRT6LMNAKDM4ETSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | claimed |
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | SIRT6 750/4885TLR7 4213/4885IL6 1079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.