Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5558817 | 0.84 | HDAC1 (0.58) | HDAC1HDAC3KDM4EALDH1A1MAPT | |
| SCHEMBL6469163 | 0.84 | KDM4E (0.60) | HDAC1HDAC3KDM4EALDH1A1MAPT | |
| SCHEMBL6335931 | 0.82 | HDAC1 (0.57) | HDAC1HDAC3KDM4EALDH1A1MAPT | |
| Anthranilamide SCHEMBL6469157 | 0.79 | PLA2G4A (0.54) | HDAC1HDAC3KDM4EALDH1A1MAPT | |
| SCHEMBL1939031 | 0.78 | HDAC3 (1.00) | HDAC1HDAC3 | |
| SCHEMBL4360657 | 0.78 | PLA2G4A (0.68) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL20751659 | 0.76 | HDAC1 (0.69) | HDAC1HDAC3KDM4EALDH1A1HDAC2 | |
| SCHEMBL4369016 | 0.75 | PLA2G4A (0.67) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL5564755 | 0.74 | KDM4E (0.55) | HDAC1HDAC3KDM4EALDH1A1MAPT | |
| SCHEMBL1938382 | 0.74 | HDAC3 (1.00) | HDAC1HDAC3KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2005508311-A | — | — | 2005-03-31 | — | — | JP | claimed |
| EP-1416928-A2 | N-MONOACYLATED DERIVATIVES OF O-PHENYLENEDIAMINES, THEIR SIX MEMBERED HETEROCYCLIC ANALOGUES AND THEIR USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-12 | — | — | EP | claimed |
| WO-2003013484-A2 | N-MONOACYLATED DERIVATIVES OF O-PHENYLENEDIAMINES, THEIR SIX MEMBERED HETEROCYCLIC ANALOGUES AND THEIR USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-20 | — | — | WO | claimed |