Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466066 | 0.89 | TDP1 (0.41) | HTTMAPTSMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL6463290 | 0.88 | KMT2A (0.40) | HTTMAPTTSHRCYP1A2CYP2C9 | |
| SCHEMBL6468914 | 0.88 | ALDH1A1 (0.43) | HTTMAPTTSHRCYP1A2CYP2C9 | |
| SCHEMBL6463902 | 0.84 | ALDH1A1 (0.54) | HTTMAPTCYP1A2CYP2C9CYP3A4 | |
| SCHEMBL5569023 | 0.80 | HTT (0.42) | HTT | |
| SCHEMBL6468063 | 0.78 | MCHR1 (0.38) | MAPTTSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5568028 | 0.77 | HTT (0.40) | HTTMEN1KMT2A | |
| SCHEMBL5558379 | 0.77 | ADRA1D (0.38) | — | |
| SCHEMBL6465067 | 0.76 | ALDH1A1 (0.47) | HTTMAPTCYP1A2CYP2C9CYP3A4 | |
| SCHEMBL5567175 | 0.76 | HTT (0.40) | HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009392-A2 | DIHYDROPYRIMIDONE INHIBITORS OF CALCIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-03 | — | — | WO | disclosed |