Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ASPH | Q12797 | 1/20 | 0.52 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.52 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.52 |
| ▸ | VNN1 | O95497 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5040442 | 0.85 | KDM4E (0.54) | HDAC3NCOR1HDAC1HDAC2HDAC8 | |
| SCHEMBL23746023 | 0.79 | HDAC1 (1.00) | HDAC3NCOR1HDAC1HDAC2HDAC8 | |
| SCHEMBL5134062 | 0.79 | OPRM1 (0.52) | HDAC3NCOR1HDAC1HDAC2HDAC8 | |
| SCHEMBL23746025 | 0.77 | HDAC1 (0.76) | HDAC3NCOR1HDAC1HDAC2HDAC8 | |
| SCHEMBL23746022 | 0.76 | HDAC3 (0.74) | HDAC3NCOR1HDAC1HDAC2HDAC8 | |
| SCHEMBL6469221 | 0.76 | MEN1 (0.57) | HDAC3NCOR1HDAC1HDAC2HDAC8 | |
| SCHEMBL11563448 | 0.75 | HCAR3 (0.64) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL2217065 | 0.74 | PLA2G10 (0.49) | KDM4EASPHRIOX2KDM8VNN1 | |
| SCHEMBL5037303 | 0.74 | SIRT6 (0.46) | HDAC3NCOR1HDAC1HDAC2HDAC8 | |
| SCHEMBL31390508 | 0.72 | P4HTM (0.47) | HDAC3NCOR1HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | claimed |
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | HDAC3 1471/4885NCOR1 1991/4885HDAC1 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.