Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 7/20 | 0.78 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | PDE4A | P27815 | 2/20 | 0.66 |
| ▸ | BLM | P54132 | 2/20 | 0.66 |
| ▸ | PDE5A | O76074 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998629 | 0.87 | PDE3A (1.00) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL10910752 | 0.85 | PDE3A (1.00) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL11230175 | 0.84 | PDE3A (0.74) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL10934165 | 0.84 | PDE3A (0.74) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL11226186 | 0.83 | PDE3A (0.86) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL11224748 | 0.82 | PDE3A (0.84) | PDE3APDE3BKDM4EHPGDPDE4A | |
| Milrinone SCHEMBL9247989 | 0.79 | PDE3A (1.00) | PDE3APDE3BKDM4EHPGDPDE4A | |
| Milrinone SCHEMBL36947 | 0.79 | PDE3A (1.00) | PDE3APDE3BKDM4EHPGDPDE4A | |
| Milrinone SCHEMBL9301167 | 0.79 | PDE3A (1.00) | PDE3APDE3BKDM4EHPGDPDE4A | |
| Milrinone SCHEMBL9309054 | 0.79 | PDE3A (1.00) | PDE3APDE3BKDM4EHPGDPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050136003-A1 | Novel chemical agents comprising a cardiotonic moiety and an imaging moiety and methods of their use | LANTHEUS MEDICAL IMAGING, INC. | 2005-06-23 | — | — | US | disclosed |
| WO-2005042033-A1 | NOVEL CHEMICAL AGENTS COMPRISING A CARDIOTONIC MOIETY AND AN IMAGING MOIETY AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050136003-A1 | Novel chemical agents comprising a cardiotonic moiety and an imaging moiety and methods of their use | TNNI3, TNNT2, TNNC1 | PDE3A 205/4885PDE3B 96/4885KDM4E 2856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.