Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GLP1R | P43220 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7889798 | 0.85 | KDM4E (0.48) | KDM4EHSD17B10ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6469853 | 0.82 | NPSR1 (0.48) | KDM4ESMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL11482936 | 0.80 | CYP1A2 (0.47) | KDM4ESMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL1338698 | 0.79 | SMN1; SMN2 (0.40) | KDM4ESMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL6094120 | 0.79 | KDM4E (0.52) | KDM4ESMN1; SMN2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL4754864 | 0.78 | KDM4E (0.55) | KDM4EHSD17B10ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5727096 | 0.77 | KDM4E (0.48) | KDM4ESMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL9044890 | 0.76 | KDM4E (0.36) | KDM4ESMN1; SMN2TP53HSD17B10ALDH1A1 | |
| SCHEMBL4203770 | 0.76 | L3MBTL1 (0.50) | KDM4ESMN1; SMN2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL1899259 | 0.74 | KDM4E (0.62) | KDM4ESMN1; SMN2ALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005011609-A2 | TRIAZOLOPURINE-BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-10 | — | — | WO | disclosed |
| WO-2004075846-A2 | PYRAZOLOPURINE-BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-09-10 | — | — | WO | disclosed |
| EP-0785937-A1 | 2-(IMIDAZOL-4-YL)CARBAPENEME DERIVATIVES, INTERMEDIATES THEREOF AND USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011932-A1 | 2-(IMIDAZOL-4-YL)CARBAPENEME DERIVATIVES, INTERMEDIATES THEREOF AND USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-25 | — | — | WO | disclosed |
| EP-0605524-A1 | ANTIBACTERIAL, ANTIMYCOPLASMAL COMPOUNDS RELATED TO MUPIROCIN | SMITHKLINE BEECHAM PLC (GB) | 1994-07-13 | — | — | EP | disclosed |