SCHEMBL647038

SCHEMBL647038

OB(O)Oc1cc(Cl)cc(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.42
MAPT P10636 1/20 0.34
CYP3A4 P08684 2/20 0.33
TPMT P51580 1/20 0.33
TP53 P04637 1/20 0.33
ALDH1A1 P00352 1/20 0.32
RECQL P46063 1/20 0.32
HSD17B10 Q99714 1/20 0.32
ERN1 O75460 2/20 0.31
IDO1 P14902 2/20 0.31
HTR3E A5X5Y0 1/20 0.31
HTR3B O95264 1/20 0.31
HTR3A P46098 1/20 0.31
HTR3D Q70Z44 1/20 0.31
HTR3C Q8WXA8 1/20 0.31
SOD1 P00441 1/20 0.31
CYP2C19 P33261 1/20 0.31
MRGPRX4 Q96LA9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31322177 0.86 ERN1 (0.31) ERN1
SCHEMBL855104 0.84 EPAS1 (0.40)
SCHEMBL31300184 0.84 RAPGEF4 (0.31) TSHRCYP3A4ALDH1A1
SCHEMBL28080318 0.84 ALDH1A1 (0.46) CYP3A4ALDH1A1ERN1CYP2C19
Propylene Glycol SCHEMBL28467029 0.82 TDP1 (0.36) MAPTCYP2C19
SCHEMBL4578633 0.80 ALDH1A1 (0.32) ALDH1A1
SCHEMBL31321546 0.80 ALDH1A1 (0.36) TSHRCYP3A4TP53ALDH1A1RECQL
SCHEMBL30718044 0.80 KCNH2 (0.40) CYP3A4
SCHEMBL27921973 0.80 TLR8 (0.37)
SCHEMBL28439900 0.78 TSHR (0.36) TSHRMAPTTPMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119331001-B Efficient narrow-band luminescent material embedded with dibenzothiophene, and preparation method and application thereof 中国科学院宁波材料技术与工程研究所 2025-06-10 CN disclosed
CN-120005686-A Composition comprising lipase and sulfite 诺维信公司 2025-05-16 CN disclosed
CN-119841785-A 5-Chloro-5-phenyl-4, 5-dihydro-isoxazole-3-carboxylic acid compound and preparation method and application thereof 郑州手性药物研究院有限公司 2025-04-18 CN disclosed
CN-119528949-A Light emitting element, condensed polycyclic compound for use in the same, and display device including the same 三星显示有限公司 2025-02-28 CN disclosed
CN-110651038-B Composition comprising lipase and sulfite 诺维信公司 2025-02-18 CN disclosed
CN-119331001-A Efficient narrow-band luminescent material embedded with dibenzothiophene, and preparation method and application thereof 中国科学院宁波材料技术与工程研究所 2025-01-21 CN disclosed
CN-112534593-B Organic light emitting diode 株式会社LG化学 2025-01-10 CN disclosed
CN-112510154-B Photoelectric conversion film and electronic device 索尼半导体解决方案公司 2024-12-20 CN disclosed
CN-112510153-B Photoelectric conversion film and electronic device 索尼半导体解决方案公司 2024-11-15 CN disclosed
CN-112531120-B Photoelectric conversion film, photoelectric conversion element, and electronic device 索尼半导体解决方案公司 2024-10-22 CN disclosed
US-20040242654-A1 Diaryl ether derivative, addition salt thereof, and immunosuppressant KYORIN PHARMACEUTICAL CO., LTD. (JP) 2004-12-02 US disclosed
EP-1137641-B1 PROCESS FOR PREPARING PYRIDAZIN-3-ON DERIVATIVES SUMITOMO CHEMICAL CO (JP) 2004-11-10 EP disclosed
EP-1431275-A1 DIARYL ETHER DERIVATIVE, ADDITION SALT THEREOF, AND IMMUNOSUPPRESSANT Kyorin Pharmaceutical Co., Ltd. (JP) 2004-06-23 EP disclosed
US-6500951-B1 RING CLOSING A CARBOXYLIC ACID DERIVATIVE IN PRESENCE OF A NITROGEN CONTAINING AROMATIC COMPOUND AND A BORON COMPOUND; HIGH YIELD AND PURITY SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-12-31 US disclosed
EP-1137641-A1 PROCESS FOR PREPARING PYRIDAZIN-3-ON DERIVATIVES SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2001-10-04 EP disclosed
EP-0873317-B1 PYRIMIDIN DERIVATIVES HOFFMANN LA ROCHE (CH) 2001-04-11 EP disclosed
WO-2000034249-A1 PROCESS FOR PREPARING PYRIDAZIN-3-ON DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-06-15 WO disclosed
EP-0873317-A1 PYRIMIDIN DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1998-10-28 EP disclosed
US-5688798-A PSYCHOTIC ILLNESS SUCH AS SCHIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1997-11-18 US disclosed
WO-1997013759-A1 PYRIMIDIN DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1997-04-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040242654-A1 Diaryl ether derivative, addition salt thereof, and immunosuppressant IL2, TSLP, HLA-DRB1 TSHR 4781/4885MAPT 4415/4885CYP3A4 277/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.