Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.40 |
| ▸ | ORAI2 | Q96SN7 | 2/20 | 0.40 |
| ▸ | ORAI3 | Q9BRQ5 | 2/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6250357 | 0.78 | LTA4H (0.33) | PCSK9LTA4HKMT2ATSHRALDH1A1 | |
| SCHEMBL27871 | 0.76 | TRPV6 (0.44) | CA4ORAI1ORAI2ORAI3TRPV6 | |
| SCHEMBL28694660 | 0.73 | ORAI1 (0.39) | CA4ORAI1ORAI2ORAI3TRPV6 | |
| SCHEMBL309077 | 0.70 | CA4 (0.48) | CA4ORAI1ORAI2ORAI3TRPV6 | |
| SCHEMBL21177785 | 0.69 | MEN1 (0.37) | CA4ORAI1ORAI2ORAI3TRPV6 | |
| SCHEMBL734634 | 0.69 | CA4 (0.46) | CA4ORAI1ORAI2ORAI3TRPV6 | |
| Water SCHEMBL27700277 | 0.69 | CA4 (0.46) | CA4ORAI1ORAI2ORAI3TRPV6 | |
| Ammonia Solution, Strong SCHEMBL28822149 | 0.69 | CA4 (0.46) | CA4ORAI1ORAI2ORAI3TRPV6 | |
| SCHEMBL9671605 | 0.68 | CA4 (0.40) | CA4LTA4HKMT2ATSHRALDH1A1 | |
| Trimethylammonium SCHEMBL8966904 | 0.67 | ORAI1 (0.43) | CA4ORAI1ORAI2ORAI3TRPV6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382213-B2 | Heterocyclic and cyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase | PROMILIAD BIOPHARMA INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150225353-A1 | Heterocyclic and Cyclic Analogs of Propargyl-Linked Inhibitors of Dihydrofolate Reductase | UNIVERSITY OF CONNECTICUT | 2015-08-13 | — | — | US | disclosed |
| WO-2005049593-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225353-A1 | Heterocyclic and Cyclic Analogs of Propargyl-Linked Inhibitors of Dihydrofolate Reductase | DHFR, DPYD, FOLR1 | CA4 4366/4885ORAI1 3317/4885ORAI2 4074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.