Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23367226 | 0.85 | NAMPT (0.49) | NAMPTCYP3A4RAB9AALDH1A1KDM4E | |
| SCHEMBL16364176 | 0.85 | NAMPT (0.49) | NAMPTCYP3A4RAB9AALDH1A1KDM4E | |
| SCHEMBL29873862 | 0.85 | NAMPT (0.49) | NAMPTCYP3A4RAB9AALDH1A1KDM4E | |
| SCHEMBL5742834 | 0.84 | CTSK (0.50) | MEN1KMT2AIDO1MAPTSYK | |
| SCHEMBL31724329 | 0.84 | NAMPT (0.48) | NAMPTCYP3A4RAB9AALDH1A1KDM4E | |
| SCHEMBL30771230 | 0.82 | NAMPT (0.47) | NAMPTCYP3A4RAB9AALDH1A1KDM4E | |
| SCHEMBL17506164 | 0.82 | NAMPT (0.47) | NAMPTCYP3A4RAB9AALDH1A1KDM4E | |
| SCHEMBL31724149 | 0.81 | ALDH1A1 (0.47) | NAMPTCYP3A4RAB9AALDH1A1KDM4E | |
| SCHEMBL14931099 | 0.80 | RAB9A (0.47) | NAMPTCYP3A4RAB9AALDH1A1MAPK1 | |
| SCHEMBL29873770 | 0.79 | NAMPT (0.47) | NAMPTCYP3A4RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049593-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-06-02 | — | — | WO | disclosed |