Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467095 | 1.00 | SIGMAR1 (0.48) | SIGMAR1MEN1KMT2AEPHX2CPB2 | |
| SCHEMBL5133310 | 1.00 | SIGMAR1 (0.48) | SIGMAR1MEN1KMT2AEPHX2CPB2 | |
| Hydrochloric Acid SCHEMBL5041625 | 0.99 | SIGMAR1 (0.47) | SIGMAR1MEN1KMT2AEPHX2CPB2 | |
| SCHEMBL6470287 | 0.85 | MEN1 (0.41) | MEN1KMT2AEPHX2CPB2ADRA1A | |
| SCHEMBL5044960 | 0.83 | CPB2 (0.41) | CPB2CYP1A2CYP2D6GABRPGABRD | |
| SCHEMBL5133309 | 0.81 | VNN1 (0.45) | SIGMAR1MEN1KMT2AOPRK1OPRM1 | |
| SCHEMBL6467093 | 0.81 | VNN1 (0.45) | SIGMAR1MEN1KMT2AOPRK1OPRM1 | |
| SCHEMBL6470743 | 0.81 | VNN1 (0.45) | SIGMAR1MEN1KMT2AOPRK1OPRM1 | |
| SCHEMBL5131617 | 0.80 | BCHE (0.58) | SIGMAR1MEN1KMT2ACPB2OPRK1 | |
| SCHEMBL20847996 | 0.79 | SIGMAR1 (0.68) | SIGMAR1MEN1KMT2AADRA1AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | SIGMAR1 2440/4885MEN1 978/4885KMT2A 2085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.