Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 3/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15662252 | 0.86 | MMP2 (0.43) | MEN1KMT2AATMPSMD14KDM4E | |
| SCHEMBL7032474 | 0.85 | IDO1 (0.61) | MEN1KMT2AATMKDM4ETP53 | |
| SCHEMBL15660691 | 0.84 | MMP2 (0.42) | MEN1KMT2AATMPSMD14KDM4E | |
| SCHEMBL15322590 | 0.82 | MEN1 (0.59) | MEN1KMT2AATMKDM4ETP53 | |
| SCHEMBL15659758 | 0.81 | PSMD14 (0.48) | MEN1KMT2APSMD14KDM4ETP53 | |
| SCHEMBL11683500 | 0.81 | MEN1 (0.57) | MEN1KMT2AATMKDM4ETP53 | |
| SCHEMBL15658228 | 0.79 | MMP2 (0.47) | MEN1KMT2AATMPSMD14KDM4E | |
| SCHEMBL15660373 | 0.77 | PSMD14 (0.44) | MEN1KMT2APSMD14KDM4EIDO1 | |
| SCHEMBL15659216 | 0.77 | MEN1 (0.57) | MEN1KMT2AKDM4EALOX15MMP2 | |
| SCHEMBL23360233 | 0.75 | KMT2A (0.64) | MEN1KMT2AATMKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050203063-A1 | Proteasome pathway inhibitors and related methods | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203063-A1 | Proteasome pathway inhibitors and related methods | PSME1, PSMC5, PSMB1 | MEN1 2839/4885KMT2A 1810/4885ATM 450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.