Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470929 | 0.81 | SMN1; SMN2 (0.41) | ALDH1A1CNR2KDM4EMEN1KMT2A | |
| SCHEMBL6531635 | 0.76 | LMNA (0.42) | LMNAPKMALDH1A1TSHRKDM4E | |
| SCHEMBL18566674 | 0.72 | GPR3 (0.58) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL15400211 | 0.68 | CNR2 (0.56) | ALDH1A1CNR2KDM4EMEN1KMT2A | |
| SCHEMBL28824473 | 0.66 | GPR3 (0.43) | LMNAPKMALDH1A1TSHRKDM4E | |
| SCHEMBL3049158 | 0.66 | L3MBTL1 (0.61) | ALDH1A1TSHRKDM4EMEN1KMT2A | |
| SCHEMBL29446458 | 0.66 | L3MBTL1 (0.61) | ALDH1A1TSHRKDM4EMEN1KMT2A | |
| SCHEMBL31384383 | 0.66 | L3MBTL1 (0.61) | ALDH1A1TSHRKDM4EMEN1KMT2A | |
| SCHEMBL10277286 | 0.66 | POLB (0.65) | LMNAALDH1A1TSHRCNR2KDM4E | |
| SCHEMBL19163665 | 0.65 | PDE7A (0.42) | LMNAALDH1A1TSHRCNR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554262-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Glenmark Pharmaceuticals Limited (IN) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004037805-A1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD. (US) | 2004-05-06 | — | — | WO | disclosed |