Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 2/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7219105 | 0.95 | CYP2E1 (0.49) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL6626248 | 0.88 | CYP2E1 (0.59) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL6136913 | 0.81 | CYP2E1 (0.39) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL7215542 | 0.81 | L3MBTL1 (0.40) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL3822143 | 0.80 | CYP2E1 (0.57) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL5400615 | 0.78 | TDP1 (0.53) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL11385986 | 0.78 | NAAA (0.41) | ALDH1A1HTT | |
| SCHEMBL31421458 | 0.77 | CYP2D6 (0.47) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL798353 | 0.77 | CYP2E1 (0.41) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 | |
| SCHEMBL23768500 | 0.77 | TDP1 (0.52) | CYP2E1CYP2C8CYP2D6CYP2A6CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182105-A1 | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY | 2005-08-18 | — | — | US | disclosed |
| US-20050182105-A1 | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182105-A1 | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function | NR3C2, NR4A3, NR3C1 | CYP2E1 731/4885CYP2C8 453/4885CYP2D6 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.