Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 3/20 | 0.51 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.51 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.51 |
| ▸ | CTSS | P25774 | 5/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.40 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.40 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.40 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479056 | 0.93 | ITGB1 (0.54) | ITGB1ITGA4ITGB7CACNA1BPSMB8 | |
| SCHEMBL6474249 | 0.91 | ITGB1 (0.52) | ITGB1ITGA4ITGB7CACNA1BPSMB8 | |
| SCHEMBL6480757 | 0.90 | ITGB1 (0.51) | ITGB1ITGA4ITGB7PSMB8ECE1 | |
| SCHEMBL6479549 | 0.89 | ITGB1 (0.49) | ITGB1ITGA4ITGB7PSMB8ECE1 | |
| SCHEMBL6473111 | 0.88 | ITGB1 (0.47) | ITGB1ITGA4ITGB7PSMB8PSMB5 | |
| SCHEMBL6474075 | 0.88 | ITGB1 (0.49) | ITGB1ITGA4ITGB7CACNA1BPSMB8 | |
| SCHEMBL6473058 | 0.86 | ITGB1 (0.48) | ITGB1ITGA4ITGB7PSMB8PSMB5 | |
| SCHEMBL6479196 | 0.83 | ACE (0.51) | ECE1ICMT | |
| SCHEMBL6479206 | 0.82 | ITGB1 (0.41) | ITGB1ITGA4ITGB7ECE1PSMB5 | |
| SCHEMBL6479211 | 0.82 | ITGB1 (0.41) | ITGB1ITGA4ITGB7ECE1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | claimed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | claimed |
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |