Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 6/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479211 | 1.00 | ITGB1 (0.41) | ITGB1ITGA4ITGB7CCR3BACE1 | |
| SCHEMBL6479196 | 0.83 | ACE (0.51) | ICMTECE1 | |
| SCHEMBL6479056 | 0.82 | ITGB1 (0.54) | ITGB1ITGA4ITGB7ICMTECE1 | |
| SCHEMBL6474096 | 0.82 | ITGB1 (0.51) | ITGB1ITGA4ITGB7ICMTECE1 | |
| SCHEMBL6474249 | 0.81 | ITGB1 (0.52) | ITGB1ITGA4ITGB7ICMTECE1 | |
| SCHEMBL6480757 | 0.80 | ITGB1 (0.51) | ITGB1ITGA4ITGB7ICMTECE1 | |
| SCHEMBL6479549 | 0.78 | ITGB1 (0.49) | ITGB1ITGA4ITGB7ICMTECE1 | |
| SCHEMBL6473095 | 0.78 | CTSL (0.62) | CTSLCTSB | |
| SCHEMBL6473111 | 0.78 | ITGB1 (0.47) | ITGB1ITGA4ITGB7PSMB1PSMB5 | |
| SCHEMBL6474075 | 0.78 | ITGB1 (0.49) | ITGB1ITGA4ITGB7PSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |