Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 12/20 | 0.52 |
| ▸ | ITGA4 | P13612 | 12/20 | 0.52 |
| ▸ | ITGB7 | P26010 | 11/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.38 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.38 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.38 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.38 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.38 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.38 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.38 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.38 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.38 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479056 | 0.94 | ITGB1 (0.54) | ITGB1ITGA4ITGB7CACNA1BICMT | |
| SCHEMBL6479549 | 0.92 | ITGB1 (0.49) | ITGB1ITGA4ITGB7ICMTL3MBTL1 | |
| SCHEMBL6474096 | 0.91 | ITGB1 (0.51) | ITGB1ITGA4ITGB7CACNA1BICMT | |
| SCHEMBL6480757 | 0.89 | ITGB1 (0.51) | ITGB1ITGA4ITGB7ICMTL3MBTL1 | |
| SCHEMBL6473111 | 0.87 | ITGB1 (0.47) | ITGB1ITGA4ITGB7PSMB8PSMB9 | |
| SCHEMBL6474075 | 0.87 | ITGB1 (0.49) | ITGB1ITGA4ITGB7CACNA1BL3MBTL1 | |
| SCHEMBL6473058 | 0.85 | ITGB1 (0.48) | ITGB1ITGA4ITGB7PSMB8PSMB9 | |
| SCHEMBL6479196 | 0.82 | ACE (0.51) | ICMTECE1 | |
| SCHEMBL6479206 | 0.81 | ITGB1 (0.41) | ITGB1ITGA4ITGB7ICMTL3MBTL1 | |
| SCHEMBL6479211 | 0.81 | ITGB1 (0.41) | ITGB1ITGA4ITGB7ICMTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | claimed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | claimed |
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |