Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 5/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.49 |
| ▸ | ITGB7 | P26010 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.38 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.38 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.38 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474249 | 0.92 | ITGB1 (0.52) | ITGB1ITGA4ITGB7L3MBTL1PSMB8 | |
| SCHEMBL6479056 | 0.91 | ITGB1 (0.54) | ITGB1ITGA4ITGB7L3MBTL1PSMB8 | |
| SCHEMBL6474096 | 0.89 | ITGB1 (0.51) | ITGB1ITGA4ITGB7KMT2AL3MBTL1 | |
| SCHEMBL6480757 | 0.86 | ITGB1 (0.51) | ITGB1ITGA4ITGB7MAPK1L3MBTL1 | |
| SCHEMBL6473111 | 0.86 | ITGB1 (0.47) | ITGB1ITGA4ITGB7KMT2AMAPK1 | |
| SCHEMBL6474075 | 0.85 | ITGB1 (0.49) | ITGB1ITGA4ITGB7MAPK1L3MBTL1 | |
| SCHEMBL6473058 | 0.83 | ITGB1 (0.48) | ITGB1ITGA4ITGB7PSMB8PSMB9 | |
| SCHEMBL6474262 | 0.81 | KMT2A (0.51) | ITGB1ITGA4ITGB7KMT2AALDH1A1 | |
| SCHEMBL6479196 | 0.79 | ACE (0.51) | ICMTECE1 | |
| SCHEMBL6661824 | 0.79 | ALDH1A1 (0.39) | KMT2AALDH1A1LMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | claimed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | claimed |
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |