Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | ECE1 | P42892 | 1/20 | 0.47 |
| ▸ | ICMT | O60725 | 1/20 | 0.47 |
| ▸ | IL1RN | P18510 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 4/20 | 0.45 |
| ▸ | CPA1 | P15085 | 2/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | NPY4R | P50391 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479206 | 0.83 | ITGB1 (0.41) | ECE1ICMT | |
| SCHEMBL6479211 | 0.83 | ITGB1 (0.41) | ECE1ICMT | |
| SCHEMBL6479056 | 0.83 | ITGB1 (0.54) | ACEECE1ICMTMMECPA1 | |
| SCHEMBL6474096 | 0.83 | ITGB1 (0.51) | ECE1ICMT | |
| SCHEMBL6474249 | 0.82 | ITGB1 (0.52) | ECE1ICMT | |
| SCHEMBL6480757 | 0.81 | ITGB1 (0.51) | ECE1ICMT | |
| SCHEMBL6479549 | 0.79 | ITGB1 (0.49) | ECE1ICMT | |
| SCHEMBL6473111 | 0.79 | ITGB1 (0.47) | — | |
| SCHEMBL6474075 | 0.79 | ITGB1 (0.49) | — | |
| SCHEMBL9832280 | 0.77 | ACE (0.64) | ACEFOLH1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |