Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 4/20 | 0.49 |
| ▸ | CASP3 | P42574 | 4/20 | 0.49 |
| ▸ | CASP7 | P55210 | 4/20 | 0.49 |
| ▸ | CASP6 | P55212 | 4/20 | 0.49 |
| ▸ | CASP8 | Q14790 | 4/20 | 0.49 |
| ▸ | YAP1 | P46937 | 8/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.40 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.40 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.40 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.40 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.40 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472835 | 0.93 | CASP1 (0.51) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6473069 | 0.92 | YAP1 (0.46) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6478978 | 0.91 | CASP1 (0.48) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6480778 | 0.90 | YAP1 (0.48) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6479150 | 0.89 | CASP1 (0.52) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6532390 | 0.85 | CASP1 (0.49) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6478253 | 0.84 | L3MBTL1 (0.42) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6472845 | 0.83 | MEN1 (0.46) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6473988 | 0.83 | YAP1 (0.42) | CASP1CASP3CASP7CASP6CASP8 | |
| SCHEMBL6473896 | 0.82 | PSMB11 (0.44) | CASP1CASP3CASP7CASP6CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | claimed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | claimed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | claimed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | claimed |
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |