SCHEMBL647487

SCHEMBL647487

COc1cc(C=C(CCC(C)[SiH2]C(O[Si](C)(C)C)O[Si](C)(C)C)C(=O)O)cc(OC)c1OC

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
POLB P06746 1/20 0.38
ALDH1A1 P00352 4/20 0.37
HPGD P15428 3/20 0.37
KDM4E B2RXH2 3/20 0.37
HTR1A P08908 2/20 0.37
HTR2C P28335 1/20 0.37
HSD17B10 Q99714 1/20 0.37
LMNA P02545 3/20 0.35
HTT P42858 2/20 0.34
GAA P10253 1/20 0.34
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
PSMB11 A5LHX3 1/20 0.33
PSMA7 O14818 1/20 0.33
PSMB1 P20618 1/20 0.33
PSMA1 P25786 1/20 0.33
PSMA2 P25787 1/20 0.33
PSMA3 P25788 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6675235 0.85 POLB (0.36) KMT2AMEN1POLBALDH1A1HPGD
SCHEMBL645502 0.82 MEN1 (0.38) KMT2AMEN1POLBALDH1A1HPGD
SCHEMBL9440575 0.81 POLB (0.38) KMT2AMEN1POLBALDH1A1HPGD
SCHEMBL646617 0.79 MEN1 (0.40) KMT2AMEN1POLBALDH1A1HPGD
SCHEMBL9119704 0.78 MEN1 (0.39) KMT2AMEN1POLBALDH1A1HPGD
SCHEMBL647364 0.77 ALDH1A1 (0.40) KMT2AMEN1POLBALDH1A1HPGD
SCHEMBL17947814 0.77 KDM4E (0.49) ALDH1A1HPGDKDM4EHTR1AHTR2C
SCHEMBL20335167 0.77 KDM4E (0.49) ALDH1A1HPGDKDM4EHTR1AHTR2C
SCHEMBL28310745 0.74 HTR1A (0.50) KMT2AMEN1POLBALDH1A1HPGD
SCHEMBL9119119 0.72 POLB (0.41) KMT2AMEN1POLBALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12383476-B2 W/O/W emulsion composition SHISEIDO COMPANY, LTD. (JP) 2025-08-12 US disclosed
WO-2024142892-A1 W/O/W EMULSIFIED COMPOSITION 株式会社 資生堂 2024-07-04 WO disclosed
WO-2024142969-A1 WATER-IN-OIL EMULSION COMPOSITION 株式会社 資生堂 2024-07-04 WO disclosed
WO-2024080367-A1 POLYSILOXANE-COATED METAL OXIDE PARTICLES, DISPERSION LIQUID, COMPOSITION, COSMETIC, AND METHOD FOR PRODUCING POLYSILOXANE-COATED METAL OXIDE PARTICLES 住友大阪セメント株式会社 2024-04-18 WO disclosed
WO-2023145102-A1 ZINC OXIDE POWDER, LIQUID DISPERSION, COATING MATERIAL, AND COSMETIC 住友大阪セメント株式会社 2023-08-03 WO disclosed
US-20220362112-A1 W/O/W EMULSION COMPOSITION SHISEIDO COMPANY, LTD. (JP) 2022-11-17 US disclosed
US-20180161255-A1 SILICON OXIDE-COATED ZINC OXIDE, COMPOSITION CONTAINING SILICON OXIDE-COATED ZINC OXIDE, AND COSMETIC PRODUCT SUMITOMO OSAKA CEMENT CO., LTD. (JP) 2018-06-14 US disclosed
EP-1974717-B1 DISPERSION OF FINE TITANIUM OXIDE PARTICLES AND COSMETIC PREPARATION CONTAINING THE SAME SHISEIDO CO LTD (JP) 2016-03-23 EP disclosed
US-8119108-B2 Dispersion of microparticulate titanium oxide and cosmetics containing the same SHISEIDO CO., LTD. (JP) 2012-02-21 US disclosed
US-20090169496-A1 Dispersion Of Microparticulate Titanium Oxide And Cosmetics Containing The Same SHISEIDO CO., LTD. (JP) 2009-07-02 US disclosed
EP-1974717-A1 DISPERSION OF FINE TITANIUM OXIDE PARTICLES AND COSMETIC PREPARATION CONTAINING THE SAME Shiseido Company, Limited (JP) 2008-10-01 EP disclosed
US-20040137019-A1 Cosmetic w/o/w emulsion preparation SHISEIDO COMPANY, LTD. (JP) 2004-07-15 US disclosed
EP-0350314-B1 Silicone type cinnamic acid derivative, preparation method thereof, uv-ray absorber, and external skin treatment agent. SHISEIDO CO LTD (JP) 1995-12-13 EP disclosed
US-5093511-A SILICONE TYPE CINNAMIC ACID DERIVATIVE, PREPARATION METHOD THEREOF, UV-RAY ABSORBER, AND EXTERNAL SKIN TREATMENT AGENT SHISEIDO COMPANY, LTD. (JP) 1992-03-03 US disclosed
EP-0350314-A2 Silicone type cinnamic acid derivative, preparation method thereof, uv-ray absorber, and external skin treatment agent. SHISEIDO COMPANY LIMITED (JP) 1990-01-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090169496-A1 Dispersion Of Microparticulate Titanium Oxide And Cosmetics Containing The Same THPO, TPSD1, TPSG1 KMT2A 3059/4885MEN1 168/4885POLB 2137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.