SCHEMBL645502

SCHEMBL645502

COc1cc(C=C(CCC[SiH2]C(O[Si](C)(C)C)O[Si](C)(C)C)C(=O)O)cc(OC)c1OC

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.38
POLB P06746 1/20 0.38
KMT2A Q03164 1/20 0.38
HTR1A P08908 4/20 0.38
HTR2C P28335 3/20 0.38
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 2/20 0.38
HPGD P15428 1/20 0.38
HSD17B10 Q99714 1/20 0.38
HTT P42858 2/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
TUBB1 Q9H4B7 3/20 0.33
PSMB11 A5LHX3 1/20 0.33
PSMA7 O14818 1/20 0.33
PSMB1 P20618 1/20 0.33
PSMA1 P25786 1/20 0.33
PSMA2 P25787 1/20 0.33
PSMA3 P25788 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9440575 0.97 POLB (0.38) MEN1POLBKMT2AHTR1AHTR2C
SCHEMBL6675235 0.84 POLB (0.36) MEN1POLBKMT2AHTR1AHTR2C
SCHEMBL647487 0.82 KMT2A (0.38) MEN1POLBKMT2AHTR1AHTR2C
SCHEMBL647364 0.80 ALDH1A1 (0.40) MEN1POLBKMT2AHTR1AHTR2C
SCHEMBL9119119 0.77 POLB (0.41) MEN1POLBKMT2AHTR1AHTR2C
SCHEMBL28310756 0.77 ALOX5 (0.51) MEN1POLBKMT2AHTR1AHTR2C
SCHEMBL9440566 0.76 POLB (0.40) MEN1POLBKMT2AHTR1AHTR2C
SCHEMBL9758218 0.76 ABCB1 (0.53) KDM4EALDH1A1ALOX5
SCHEMBL9758206 0.76 ABCB1 (0.53) KDM4EALDH1A1ALOX5
SCHEMBL9440516 0.76 POLB (0.40) MEN1POLBKMT2AHTR1AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12383476-B2 W/O/W emulsion composition SHISEIDO COMPANY, LTD. (JP) 2025-08-12 US disclosed
WO-2024142969-A1 WATER-IN-OIL EMULSION COMPOSITION 株式会社 資生堂 2024-07-04 WO disclosed
WO-2024142892-A1 W/O/W EMULSIFIED COMPOSITION 株式会社 資生堂 2024-07-04 WO disclosed
WO-2024080367-A1 POLYSILOXANE-COATED METAL OXIDE PARTICLES, DISPERSION LIQUID, COMPOSITION, COSMETIC, AND METHOD FOR PRODUCING POLYSILOXANE-COATED METAL OXIDE PARTICLES 住友大阪セメント株式会社 2024-04-18 WO disclosed
WO-2023210618-A1 SURFACE-TREATED ZINC OXIDE PARTICLES, DISPERSION LIQUID, COSMETIC MATERIAL, METHOD FOR PRODUCING SURFACE-TREATED ZINC OXIDE PARTICLES 住友大阪セメント株式会社 2023-11-02 WO disclosed
WO-2023190487-A1 SURFACE-MODIFIED ZINC OXIDE PARTICLES, DISPERSION LIQUID AND COSMETIC PREPARATION 住友大阪セメント株式会社 2023-10-05 WO disclosed
WO-2023145102-A1 ZINC OXIDE POWDER, LIQUID DISPERSION, COATING MATERIAL, AND COSMETIC 住友大阪セメント株式会社 2023-08-03 WO disclosed
US-20220362112-A1 W/O/W EMULSION COMPOSITION SHISEIDO COMPANY, LTD. (JP) 2022-11-17 US disclosed
WO-2022177004-A1 SURFACE-MODIFIED ZINC OXIDE PAPRTICLES, DISPERSION LIQUID, COSMETIC PREPARATION, AND METHOD FOR PRODUCING SURFACE-MODIFIED ZINC OXIDE PARTICLES 住友大阪セメント株式会社 2022-08-25 WO disclosed
US-20180161255-A1 SILICON OXIDE-COATED ZINC OXIDE, COMPOSITION CONTAINING SILICON OXIDE-COATED ZINC OXIDE, AND COSMETIC PRODUCT SUMITOMO OSAKA CEMENT CO., LTD. (JP) 2018-06-14 US disclosed
EP-1974717-B1 DISPERSION OF FINE TITANIUM OXIDE PARTICLES AND COSMETIC PREPARATION CONTAINING THE SAME SHISEIDO CO LTD (JP) 2016-03-23 EP disclosed
US-8119108-B2 Dispersion of microparticulate titanium oxide and cosmetics containing the same SHISEIDO CO., LTD. (JP) 2012-02-21 US disclosed
US-20090169496-A1 Dispersion Of Microparticulate Titanium Oxide And Cosmetics Containing The Same SHISEIDO CO., LTD. (JP) 2009-07-02 US disclosed
EP-1974717-A1 DISPERSION OF FINE TITANIUM OXIDE PARTICLES AND COSMETIC PREPARATION CONTAINING THE SAME Shiseido Company, Limited (JP) 2008-10-01 EP disclosed
EP-1369101-A1 COSMETIC W/O/W EMULSION PREPARATION SHISEIDO COMPANY LIMITED (JP) 2003-12-10 EP disclosed
EP-0350314-B1 Silicone type cinnamic acid derivative, preparation method thereof, uv-ray absorber, and external skin treatment agent. SHISEIDO CO LTD (JP) 1995-12-13 EP disclosed
US-5315022-A Sunscreen SHISEIDO COMPANY LTD. (JP) 1994-05-24 US disclosed
US-5093511-A SILICONE TYPE CINNAMIC ACID DERIVATIVE, PREPARATION METHOD THEREOF, UV-RAY ABSORBER, AND EXTERNAL SKIN TREATMENT AGENT SHISEIDO COMPANY, LTD. (JP) 1992-03-03 US disclosed
EP-0350314-A2 Silicone type cinnamic acid derivative, preparation method thereof, uv-ray absorber, and external skin treatment agent. SHISEIDO COMPANY LIMITED (JP) 1990-01-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090169496-A1 Dispersion Of Microparticulate Titanium Oxide And Cosmetics Containing The Same THPO, TPSD1, TPSG1 MEN1 168/4885POLB 2137/4885KMT2A 3059/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.