Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | DRD4 | P21917 | 6/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | HTR1B | P28222 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6474672 | 0.99 | MEN1 (0.66) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL6475306 | 0.85 | HTR1A (0.56) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL8011055 | 0.82 | CYP2D6 (0.88) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL84137 | 0.82 | HTR1A (0.72) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL13314093 | 0.82 | HTR1A (0.75) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL18211393 | 0.80 | HTR1A (0.86) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL19568202 | 0.80 | CYP2D6 (0.86) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL29786717 | 0.80 | ADRA1A (1.00) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL4014204 | 0.80 | ADRA1A (1.00) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL7778600 | 0.79 | ADRA1A (0.66) | HTR1AADRA1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894052-B1 | Serotonergic receptor antagonist | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2005-05-17 | — | — | US | claimed |
| EP-1000046-B1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI CHEM PHARM (CH) | 2003-11-26 | — | — | EP | claimed |
| JP-2001512111-A | — | — | 2001-08-21 | — | — | JP | claimed |
| EP-1000046-A1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 2000-05-17 | — | — | EP | claimed |
| WO-1999006383-A1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-02-11 | — | — | WO | claimed |