Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | DRD4 | P21917 | 6/20 | 0.71 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.71 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | MTOR | P42345 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | HTR1B | P28222 | 1/20 | 0.71 |
| ▸ | HTR7 | P34969 | 1/20 | 0.71 |
| ▸ | HTR2B | P41595 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011055 | 0.86 | CYP2D6 (0.88) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL13314093 | 0.86 | HTR1A (0.75) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL4014204 | 0.84 | ADRA1A (1.00) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL19568202 | 0.84 | CYP2D6 (0.86) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL29786717 | 0.84 | ADRA1A (1.00) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL18211393 | 0.84 | HTR1A (0.86) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL29387395 | 0.83 | CYP2D6 (1.00) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| SCHEMBL13314094 | 0.83 | HTR1A (1.00) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| Way-100,635 SCHEMBL29451114 | 0.83 | HTR1A (1.00) | HTR1AADRA1ACYP2D6CYP3A4DRD4 | |
| Way-100,635 SCHEMBL13398069 | 0.83 | HTR1A (1.00) | HTR1AADRA1ACYP2D6CYP3A4DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127357-A | N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides | JOHN WYETH & BROTHER, LTD. (GB) | 2000-10-03 | — | — | US | claimed |
| EP-0512755-B1 | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1994-12-14 | — | — | EP | claimed |
| EP-0512755-A2 | Piperazine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1992-11-11 | — | — | EP | claimed |
| EP-1817269-B1 | USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED AMIDES USING PHOTO-INDUCED FREE RADICAL CARBONYLATION | GE HEALTHCARE LTD (GB) | 2013-01-02 | — | — | EP | disclosed |
| US-8129528-B2 | Method for the use of [11 C] carbon monoxide in labeling synthesis of 11C-labelled amides using metal amides and photo-induced free radical carbonylation | GE HEALTHCARE LIMITED (GB) | 2012-03-06 | — | — | US | disclosed |
| US-8129528-B2 | Method for the use of [11 C] carbon monoxide in labeling synthesis of 11C-labelled amides using metal amides and photo-induced free radical carbonylation | GE HEALTHCARE LIMITED (GB) | 2012-03-06 | — | — | US | disclosed |
| US-20090297445-A1 | METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED AMIDES USING METAL AMIDES AND PHOT-INDUCED FREE RADICAL CARBONYLATION | ITSENKO OLEKSIY | 2009-12-03 | — | — | US | disclosed |
| US-20090297445-A1 | METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED AMIDES USING METAL AMIDES AND PHOT-INDUCED FREE RADICAL CARBONYLATION | ITSENKO OLEKSIY | 2009-12-03 | — | — | US | disclosed |
| US-7553942-B2 | Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled amides using metal amides and photo-induced free radical carbonylation | GE HEALTHCARE LIMITED (GB) | 2009-06-30 | — | — | US | disclosed |
| US-7553942-B2 | Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled amides using metal amides and photo-induced free radical carbonylation | GE HEALTHCARE LIMITED (GB) | 2009-06-30 | — | — | US | disclosed |
| US-6127357-A | N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides | JOHN WYETH & BROTHER, LTD. (GB) | 2000-10-03 | — | — | US | disclosed |
| EP-0512755-B1 | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1994-12-14 | — | — | EP | disclosed |
| EP-0512755-A2 | Piperazine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090297445-A1 | METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED AMIDES USING METAL AMIDES AND PHOT-INDUCED FREE RADICAL CARBONYLATION | HCCS, PPOX, PAM | HTR1A 1717/4885ADRA1A 2207/4885CYP2D6 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.