SCHEMBL6476937

SCHEMBL6476937

CC1=C2C=C(C(=O)NCc3ccccc3)SN2C(=O)C(Cc2ccc(F)cc2)C1=O

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.41
CNR2 P34972 1/20 0.41
KMT2A Q03164 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C19 P33261 1/20 0.41
TRPA1 O75762 1/20 0.41
MAPT P10636 3/20 0.40
LMNA P02545 5/20 0.40
ALDH1A1 P00352 4/20 0.40
KDM4E B2RXH2 1/20 0.40
HPGD P15428 1/20 0.40
RAB9A P51151 1/20 0.40
SCD O00767 1/20 0.40
HTT P42858 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
HTR7 P34969 1/20 0.39
MEN1 O00255 1/20 0.39
ALOX12 P18054 1/20 0.39
RECQL P46063 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6822190 0.91 ALDH1A1 (0.36) SMN1; SMN2CNR2KMT2ACYP1A2CYP2C19
SCHEMBL6477867 0.80 ALDH1A1 (0.41) SMN1; SMN2CNR2KMT2ACYP1A2CYP2C19
SCHEMBL6292804 0.70 MAPT (0.46) SMN1; SMN2CNR2KMT2ACYP1A2CYP2C19
SCHEMBL6288765 0.69 HPGD (0.47) SMN1; SMN2CNR2KMT2ACYP1A2CYP2C19
SCHEMBL6488759 0.66 CES2 (0.43) CYP1A2CYP2C19ALDH1A1KDM4EHPGD
SCHEMBL1155517 0.66 ALDH1A1 (0.72) KMT2ACYP1A2CYP2C19LMNAALDH1A1
SCHEMBL6477069 0.65 S1PR3 (0.39) SMN1; SMN2KMT2ACYP1A2CYP2C19ALDH1A1
SCHEMBL6813863 0.65 L3MBTL1 (0.47) LMNAALDH1A1L3MBTL1
SCHEMBL6682933 0.65 TRPA1 (0.44) SMN1; SMN2CNR2KMT2ACYP1A2CYP2C19
SCHEMBL6484455 0.64 PTGER4 (0.38) SMN1; SMN2CYP1A2CYP2C19MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004014908-A1 HETEROBICYLCIC METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 WO claimed
US-6897223-B2 Pyridine fused bicyclic metalloproteinase inhibitors WARNER-LAMBERT COMPANY (US) 2005-05-24 US disclosed