SCHEMBL6476984

SCHEMBL6476984

Cn1c(=O)n(Cc2ccccc2)c(=O)c2c(C(=O)OC3CCOCC3)csc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR3E A5X5Y0 1/20 0.41
HTR3B O95264 1/20 0.41
HTR3A P46098 1/20 0.41
HTR3D Q70Z44 1/20 0.41
HTR3C Q8WXA8 1/20 0.41
GAA P10253 2/20 0.40
TSHR P16473 2/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
ERCC5 P28715 1/20 0.39
FEN1 P39748 1/20 0.39
SCN1A P35498 2/20 0.39
SCN2A Q99250 2/20 0.39
SCN3A Q9NY46 2/20 0.39
MAPT P10636 3/20 0.39
ALDH1A1 P00352 3/20 0.39
PKM P14618 2/20 0.39
KDM4E B2RXH2 2/20 0.39
CYP3A4 P08684 2/20 0.39
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6472546 0.90 SCN1A (0.51) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL7101979 0.84 HTR3E (0.40) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL6471463 0.83 BCHE (0.46) CYP2D6ALDH1A1KDM4ECYP3A4CYP1A2
SCHEMBL7017390 0.82 DRD2 (0.42) GAATSHRERCC5FEN1MAPT
SCHEMBL6473485 0.82 ALDH1A1 (0.48) GAATSHRCYP2D6CYP2C19MAPT
SCHEMBL6473589 0.80 CYP1A2 (0.46) ERCC5FEN1MAPTALDH1A1KDM4E
SCHEMBL6257579 0.80 DRD2 (0.41) GAATSHRERCC5FEN1MAPT
SCHEMBL6471284 0.80 MEN1 (0.46) TSHRERCC5FEN1MAPTALDH1A1
SCHEMBL7106875 0.80 KMT2A (0.39) HTR3EHTR3BHTR3AHTR3DHTR3C
SCHEMBL7101392 0.80 CHRM2 (0.41) GAATSHRERCC5FEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1530475-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
WO-2004006931-A2 PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
EP-1370562-A1 THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS Warner-Lambert Company LLC (US) 2003-12-17 EP disclosed
WO-2002064598-A1 THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2002-08-22 WO disclosed