SCHEMBL6473589

SCHEMBL6473589

Cn1c(=O)n(Cc2ccccc2)c(=O)c2c(C(=O)OCC3CCCCO3)csc21

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C8 P10632 1/20 0.46
CYP2C9 P11712 1/20 0.46
ADORA2B P29275 1/20 0.46
ALDH1A1 P00352 2/20 0.43
MAPT P10636 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HIF1A Q16665 1/20 0.43
LMNA P02545 1/20 0.43
MAPK1 P28482 1/20 0.43
MGLL Q99685 2/20 0.41
KDM4E B2RXH2 1/20 0.39
HPGD P15428 1/20 0.39
HSD17B10 Q99714 1/20 0.39
ERCC5 P28715 1/20 0.39
FEN1 P39748 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7101392 0.88 CHRM2 (0.41) CYP3A4ALDH1A1MAPTSMN1; SMN2LMNA
SCHEMBL6257579 0.87 DRD2 (0.41) CYP3A4ALDH1A1MAPTSMN1; SMN2LMNA
SCHEMBL7017390 0.86 DRD2 (0.42) CYP3A4ALDH1A1MAPTSMN1; SMN2LMNA
SCHEMBL6473136 0.83 L3MBTL1 (0.48) ALDH1A1MAPTSMN1; SMN2LMNAMAPK1
SCHEMBL6471284 0.81 MEN1 (0.46) CYP3A4ADORA2BALDH1A1MAPTSMN1; SMN2
SCHEMBL6727817 0.81 ALDH1A1 (0.45) ALDH1A1MAPTSMN1; SMN2HIF1ALMNA
SCHEMBL6476984 0.80 HTR3E (0.41) CYP1A2CYP3A4CYP2C8CYP2C9ADORA2B
SCHEMBL6474542 0.80 ADORA2B (0.44) CYP3A4ADORA2BALDH1A1SMN1; SMN2HIF1A
SCHEMBL6259138 0.79 SRC (0.48) CYP1A2CYP3A4CYP2C9ADORA2BALDH1A1
SCHEMBL6471776 0.79 TSHR (0.45) CYP3A4ALDH1A1MAPTSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1530475-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 Warner-Lambert Company LLC (US) 2005-05-18 EP disclosed
WO-2004006931-A2 PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
EP-1370562-A1 THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS Warner-Lambert Company LLC (US) 2003-12-17 EP disclosed
WO-2002064598-A1 THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2002-08-22 WO disclosed