Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487506 | 0.88 | PTGS2 (0.57) | PTGS2PTGS1ALOX5KDM4EALDH1A1 | |
| SCHEMBL6477263 | 0.76 | PTGS2 (0.71) | PTGS2PTGS1ALOX5THRBKMT2A | |
| SCHEMBL6477175 | 0.74 | PTGS2 (1.00) | PTGS2PTGS1ALOX5THRBTGFBR1 | |
| SCHEMBL6476216 | 0.74 | PTGS2 (1.00) | PTGS2PTGS1ALOX5THRBTGFBR1 | |
| SCHEMBL7546592 | 0.74 | PTGS2 (0.46) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6290043 | 0.73 | PTGS2 (0.62) | PTGS2PTGS1ALOX5THRBTGFBR1 | |
| SCHEMBL6477322 | 0.72 | PTGS2 (1.00) | PTGS2PTGS1ALOX5 | |
| SCHEMBL7493792 | 0.68 | PTGS2 (0.33) | PTGS2PTGS1ALOX5 | |
| SCHEMBL9532243 | 0.66 | PTGS2 (0.75) | PTGS2PTGS1ALOX5KDM4EALDH1A1 | |
| SCHEMBL25970688 | 0.64 | CYP2A6 (0.43) | THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936632-B2 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | MERCKLE GMBH (DE) | 2005-08-30 | — | — | US | disclosed |
| US-20040122002-A1 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | MERCKLE GMBH (DE) | 2004-06-24 | — | — | US | disclosed |
| EP-1246825-B1 | FUSED PYRROLE COMPOUNDS, PHARMACEUTICAL AGENTS CONTAINING THE SAME, AND THE USE THEREOF | MERCKLE GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122002-A1 | Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof | PTGS1, PTGS2, PTGER1 | PTGS2 2/4885PTGS1 1/4885ALOX5 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.