Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6483700 | 0.85 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL6477010 | 0.81 | TSHR (0.66) | ALDH1A1SMN1; SMN2RAB9ATSHRMAPT | |
| SCHEMBL9589803 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL9588299 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL5935559 | 0.72 | HCAR2 (0.44) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL6486014 | 0.72 | MTNR1A (0.47) | KDM4EALDH1A1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL9590027 | 0.71 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL9589866 | 0.70 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL9270572 | 0.70 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL6487606 | 0.70 | SIGMAR1 (0.59) | ALDH1A1SMN1; SMN2RAB9ATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919362-B2 | Heterocyclic derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-07-19 | — | — | US | disclosed |
| EP-1252150-B1 | HETEROCYCLIC DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2003-06-04 | — | — | EP | disclosed |
| US-20030040533-A1 | Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2003-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030040533-A1 | Novel heterocyclic derivatives, preparation method and pharmaceutical compositions containing same | CYP2F1, CYP11B2, CYP4B1 | KDM4E 3486/4885ALDH1A1 687/4885SMN1; SMN2 1823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.