SCHEMBL6477901

SCHEMBL6477901

CCOC(=O)[C@H](O)[C@@H](O)c1ccc(OC)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.51
KMT2A Q03164 3/20 0.44
HDAC3 O15379 2/20 0.44
HDAC4 P56524 2/20 0.44
HDAC1 Q13547 2/20 0.44
HDAC7 Q8WUI4 2/20 0.44
HDAC2 Q92769 2/20 0.44
HDAC10 Q969S8 2/20 0.44
HDAC11 Q96DB2 2/20 0.44
HDAC8 Q9BY41 2/20 0.44
HDAC6 Q9UBN7 2/20 0.44
HDAC9 Q9UKV0 2/20 0.44
HDAC5 Q9UQL6 2/20 0.44
GLA P06280 1/20 0.44
HPGD P15428 2/20 0.43
AOC3 Q16853 1/20 0.42
ALDH1A1 P00352 3/20 0.42
GAA P10253 2/20 0.42
KDM4E B2RXH2 2/20 0.42
LMNA P02545 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6744209 1.00 ALOX15 (0.51) ALOX15KMT2AHDAC3HDAC4HDAC1
SCHEMBL6872391 1.00 ALOX15 (0.51) ALOX15KMT2AHDAC3HDAC4HDAC1
SCHEMBL8776709 0.87 ALOX15 (0.49) ALOX15KMT2AHDAC3HDAC4HDAC1
SCHEMBL8776680 0.87 ALOX15 (0.49) ALOX15KMT2AHDAC3HDAC4HDAC1
SCHEMBL11764494 0.87 ALOX15 (0.51) ALOX15KMT2AHDAC3HDAC4HDAC1
SCHEMBL27620766 0.84 MEN1 (0.45) KMT2AALDH1A1GAALMNAMEN1
SCHEMBL10480695 0.84 RAB9A (0.47) KMT2AAOC3MEN1NPC1RAB9A
SCHEMBL7082815 0.84 RAB9A (0.47) KMT2AAOC3MEN1NPC1RAB9A
SCHEMBL9393808 0.84 ALOX15 (0.49) ALOX15KMT2AHDAC3HDAC4HDAC1
SCHEMBL25924790 0.84 ALOX15 (0.49) ALOX15KMT2AHDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6881839-B2 Process for preparing diltiazem using a heterogeneous trifunctional catalyst COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2005-04-19 US claimed
US-20040127704-A1 Process for preparing diltiazem using a heterogeneous trifunctional catalyst COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2004-07-01 US claimed
EP-4656201-A2 RAS INHIBITORS Revolution Medicines, Inc. (US) 2025-12-03 EP disclosed
EP-4615823-A2 COMPOUNDS, COMPLEXES, AND METHODS FOR THEIR PREPARATION AND OF THEIR USE Revolution Medicines, Inc. (US) 2025-09-17 EP disclosed
US-20250269037-A1 COMPOUNDS, COMPLEXES, AND METHODS FOR THEIR PREPARATION AND OF THEIR USE WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2025-08-28 US disclosed
US-20250051306-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2025-02-13 US disclosed
US-20240262847-A1 COVALENT RAS INHIBITORS AND USES THEREOF WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2024-08-08 US disclosed
WO-2024102421-A2 COMPOUNDS, COMPLEXES, AND METHODS FOR THEIR PREPARATION AND OF THEIR USE Revolution Medicines, Inc. (US) 2024-05-16 WO disclosed
EP-4334324-A1 COVALENT RAS INHIBITORS AND USES THEREOF Revolution Medicines, Inc. (US) 2024-03-13 EP disclosed
US-11739074-B2 Ras inhibitors Revolution Medicines, Inc. (US) 2023-08-29 US disclosed
US-11739074-B2 Ras inhibitors Revolution Medicines, Inc. (US) 2023-08-29 US disclosed
US-20230233569-A1 METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2023-07-27 US disclosed
EP-4208261-A1 USE OF SOS1 INHIBITORS TO TREAT MALIGNANCIES WITH SHP2 MUTATIONS Revolution Medicines, Inc. (US) 2023-07-12 EP disclosed
WO-2022235866-A1 COVALENT RAS INHIBITORS AND USES THEREOF Revolution Medicines, Inc. (US) 2022-11-10 WO disclosed
EP-4054720-A1 RAS INHIBITORS Revolution Medicines, Inc. (US) 2022-09-14 EP disclosed
WO-2022060583-A1 USE OF SOS1 INHIBITORS TO TREAT MALIGNANCIES WITH SHP2 MUTATIONS Revolution Medicines, Inc. (US) 2022-03-24 WO disclosed
US-20210130326-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2021-05-06 US disclosed
US-6881839-B2 Process for preparing diltiazem using a heterogeneous trifunctional catalyst COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2005-04-19 US disclosed
WO-2004058734-A1 PROCESS FOR PREPARING DILTIAZEM USING A HETEROGENEOUS TRIFUNCTIONAL CATALYST COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2004-07-15 WO disclosed
US-20040127704-A1 Process for preparing diltiazem using a heterogeneous trifunctional catalyst COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2004-07-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250051306-A1 RAS INHIBITORS KRAS, NRAS, HRAS ALOX15 4589/4885KMT2A 3685/4885HDAC3 2510/4885
US-11739074-B2 Ras inhibitors KRAS, NRAS, HRAS ALOX15 4399/4885KMT2A 3873/4885HDAC3 3007/4885
US-20210130326-A1 RAS INHIBITORS KRAS, NRAS, HRAS ALOX15 4589/4885KMT2A 3685/4885HDAC3 2510/4885
US-20240262847-A1 COVALENT RAS INHIBITORS AND USES THEREOF KRAS, NRAS, HRAS ALOX15 4451/4885KMT2A 2080/4885HDAC3 1174/4885
US-20040127704-A1 Process for preparing diltiazem using a heterogeneous trifunctional catalyst CYP2W1, INMT, TST ALOX15 649/4885KMT2A 1171/4885HDAC3 2336/4885
US-20230233569-A1 METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS KRAS, HRAS, MTOR ALOX15 3782/4885KMT2A 3021/4885HDAC3 1181/4885
US-20250269037-A1 COMPOUNDS, COMPLEXES, AND METHODS FOR THEIR PREPARATION AND OF THEIR USE PAICS, ORC3, SSB ALOX15 3982/4885KMT2A 3038/4885HDAC3 1600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.