Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6527386 | 0.76 | HPGD (0.45) | LMNACYP1A2SMN1; SMN2KDM4EPOLB | |
| SCHEMBL11400180 | 0.73 | NPC1 (0.41) | KDM4EPOLBKIF11KMT2A | |
| Hydrochloric Acid SCHEMBL11409978 | 0.72 | ALOX15 (0.43) | LMNACYP1A2AGTR1CA12CA1 | |
| SCHEMBL28290663 | 0.71 | CA1 (0.50) | LMNACA12CA1CA2CA4 | |
| SCHEMBL5309997 | 0.70 | MEN1 (0.42) | LMNACA12CA1CA2CA4 | |
| SCHEMBL11519771 | 0.69 | CA1 (0.48) | LMNACYP1A2AGTR1CA12CA1 | |
| SCHEMBL28187264 | 0.68 | CA1 (0.56) | LMNACYP1A2CA12CA1CA2 | |
| SCHEMBL7145599 | 0.67 | KIF11 (0.38) | KIF11TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10586377 | 0.67 | TAAR1 (0.38) | LMNACYP1A2AGTR1SMN1; SMN2KDM4E | |
| SCHEMBL4582899 | 0.67 | ADRA2A (0.62) | LMNACYP1A2AGTR1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005079284-A2 | METHODS AND REAGENTS FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH INCREASED LEVELS OF PROINFLAMMATORY CYTOKINES | COMBINATORX, INCORPORATED (US) | 2005-09-01 | — | — | WO | disclosed |