Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127282 | 0.81 | CYP2D6 (0.47) | CYP2D6CYP2C19NOS3NOS1NOS2 | |
| SCHEMBL22086465 | 0.81 | HSP90AA1 (0.39) | CYP2D6CYP2C19NOS3NOS1NOS2 | |
| SCHEMBL28442615 | 0.80 | CYP2D6 (0.40) | CYP2D6CYP2C19NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL8742974 | 0.79 | CYP2D6 (0.45) | CYP2D6CYP2C19NOS3NOS1NOS2 | |
| SCHEMBL22086466 | 0.76 | L3MBTL1 (0.37) | CYP2D6CYP2C19NOS3NOS1NOS2 | |
| SCHEMBL3361750 | 0.74 | ALDH1A1 (0.42) | CYP2D6CYP2C19NOS3NOS1NOS2 | |
| SCHEMBL3394969 | 0.74 | HSP90AA1 (0.33) | CYP2D6CYP2C19L3MBTL1KDM4ETDP1 | |
| SCHEMBL13338823 | 0.73 | TAAR1 (0.41) | CYP2D6CYP2C19L3MBTL1KDM4ELMNA | |
| SCHEMBL8202219 | 0.69 | CYP2D6 (0.48) | CYP2D6CYP2C19NOS3NOS1NOS2 | |
| SCHEMBL18880684 | 0.69 | NOS3 (0.36) | CYP2D6CYP2C19NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6864255-B2 | Substituted triazinyl amide derivatives and methods of use | AMGEN INC. (US) | 2005-03-08 | — | — | US | disclosed |
| US-20030087908-A1 | Substituted triazinyl amide derivatives and methods of use | AMGEN INC. | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087908-A1 | Substituted triazinyl amide derivatives and methods of use | FLT4, FLT1, VEGFA | CYP2D6 257/4885CYP2C19 214/4885NOS3 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.